Coronary Microvascular Dysfunction, Obstructive Coronary Heart Disease
Conditions
Keywords
two-dimensional speckle tracking imaging, strain, coronary microvascular dysfunction
Brief summary
The study was designed to evaluate the left ventricular longitudinal strain and strain rate assessed by 2D-STI in patients with coronary microvascular dysfunction (CMD) or obstructive coronary artery disease (CAD) , to investigate the effect of different types of ischemic heart disease on the LV systolic function, and to explore the value of LS on the diagnosis of coronary microvascular dysfunction.
Detailed description
A total of 175 patients with chest pain, without wall motion abnormality and without significant coronary artery stenosis (\<50%) assessed by coronary angiography or coronary computed tomography were enrolled from July 2011 to December 2017. Coronary flow reserve (CFR) of these patients were detected by transthoracic Doppler echocardiography. The patients were divided into coronary microvascular dysfunction group ( CFR≤2.5, n=67) and control group (CFR\>2.5, n=108). At the same time, 67 age-matched patients with any major coronary arteries stenosis≥50% and without wall motion abnormality were involved into the obstructive coronary artery disease group. Parameters of global longitudinal strain (LS) and strain rate, subendocardial LS and subepicardial LS were quantified by 2D-STI, the differences of these parameters among three groups were analyzed，correlation analysis、univariate and multivariate analysis and receiver operating characteristic curve were used.
Interventions
DIAGNOSTIC_TESTTwo dimensional speckle tracking imaging
lobal longitudinal strain and strain rate, subendocardial LS and subepicardial LS were quantified by two dimensional speckle tracking imaging
Sponsors
Peking University Third Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* age from 18-85 years
Exclusion criteria
* patients with history of myocardial infarction or abnormal wall motion suggested by conventional echocardiography * patients with acute heart failure, chronic heart failure or LVEF values less than 50% * patients with congenital heart disease, severe valvular disease, severe bradycardia, high atrioventricular block and atrial fibrillation * patients who did not store ultrasound images or whose ultrasound images were unclear * patients who had incomplete clinical data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| global longitudinal strain | 15/3/2018-30/12/2018 | global longitudinal strain of CMD group and obstructive CAD group |
Countries
China
Outcome results
None listed