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Termination of Persistent Atrial Fibrillation by Catheter Ablation

A Prospective, Multicenter, Cohort Study of Termination of Persistent Atrial Fibrillation by Catheter Ablation

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04958928
Enrollment
400
Registered
2021-07-12
Start date
2021-08-01
Completion date
2023-08-01
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation

Brief summary

This is a prospective, multicenter, cohort study aims to demonstrate the role of termination of AF in ablation for persistent atrial fibrillation, and evaluate the clinical outcomes in patients with or without AF termination.

Interventions

PROCEDURECatheter ablation

All patients received radiofrequncy ablation.

Sponsors

Wuhan Central Hospital
CollaboratorOTHER
Ruijin Hospital
CollaboratorOTHER
Beijing Chao Yang Hospital
CollaboratorOTHER
The Third Xiangya Hospital of Central South University
CollaboratorOTHER
The First Affiliated Hospital of Dalian Medical University
CollaboratorOTHER
Xiamen Cardiovascular Hospital, Xiamen University
CollaboratorOTHER
The Third People's Hospital of Chengdu
CollaboratorOTHER
Shanghai Chest Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

1\. Aged 18 to 80 years old; 2. Persistent AF; 3. Nonresponse or intolerance to ≥1 antiarrhythmic drug.

Exclusion criteria

1. With uncontrolled congestive heart failure; 2. Having significant valvular disease and/or prosthetic heart valve(s); 3. With myocardial infarction or stroke within 6 months of screening; 4. With Significant congenital heart disease; 5. Ejection fraction was \<40% measured by echocardiography; 6. Allergic to contrast media; 7. Contraindication to anticoagulation medications; 8. Severe pulmonary disease e.g. restrictive pulmonary disease, chronic obstructive disease (COPD); 9. Left atrial (LA) thrombus measured by pre-procedure transesophageal echocardiography; 10. Having any contraindication to right or left sided heart catheterization; 11. Previous atrial fibrillation ablation; 12\. Presence of an implanted cardioverter-defibrillator; 13. Any cardiac surgery within the past 2 months; 14. Poor general health; 15.Life expectancy less than 6 months.

Design outcomes

Primary

MeasureTime frameDescription
AF recurrence rate12 monthsAF recurrence is defined as presence of documented AF episodes of 30 recurrence is defined as presence of documented AF episodes of 30 seconds or longer duration.

Contacts

Primary ContactQin Mu, MD
qinmuae@163.com+8613052320103

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026