Familial Hypercholesterolemia
Conditions
Keywords
familial hypercholesterolemia, prognosis
Brief summary
To determine the prevalence and the prognosis in a corhort of patients with familial hypercholesterolemia (FH).
Detailed description
This study aims to achieve the following goals through prospective cohort study and statistical analysis: (1) to determine the prevalence of familial hypercholesterolemia (FH) in healthy people with hypercholesterolemia.（2) Compared with non FH population, the relative risk of atherosclerotic cardiovascular disease (ASCVD) in FH patients in China was calculated, and the risk prediction model of ASCVD in FH patients was constructed by using biochemical results, imaging data, biomarkers and other indicators.（3) To evaluate the benefits of different lipid-lowering strategies for FH patients in China.（4) To analyze the gene carriers of FH patients in China.
Interventions
OTHERfamilial hypercholesterolemia
Among the selected patients with hyperlipidemia, those who met the diagnostic criteria of FH were included in the study cohort as FH group.
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\) Patients with definite diagnosis of hyperlipidemia.
Exclusion criteria
1. Age \< 18. 2. Do not agree to participate in this study. 3. secondary hypercholesterolemia. 4. Phytosteronemia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with atherosclerotic cardiovascular disease (ASCVD) events | 2 years from enrollmet | 1\) Fatal or non-fatal myocardial infarction; 2) Fatal or non-fatal ischemic stroke; 3) Coronary artery revascularization; 4) Peripheral artery revascularization; 5) Cardiogenic death |
Contacts
Primary ContactWei Gao, Doctor
Outcome results
None listed