Insulin Resistance, Postprandial Hyperglycemia
Conditions
Keywords
glucose tolerance, meal timing, insulin, postprandial, walking
Brief summary
Randomised crossover trial to compare early vs late walking on postprandial glycaemic response at night time.
Detailed description
In this crossover trial, eligible participants will be randomised to a 30-minute bout of physical activity (30 minute walk) either during the day or after an evening meal. The postprandial response to the evening meal will be analysed.
Interventions
OTHEREarly exercise
Participants will exercise for 30 minutes prior to an evening meal.
OTHERLate exercise
Participants will exercise for 30 minutes after an evening meal.
Sponsors
Monash University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Investigator)
Masking description
This is a single masking study.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and Women aged 18 to 65 years of age * Waist circumference of \<94cm and \<80cm for Caucasian males and females, respectively * Waist circumference of \<90cm and \<80 cm for Asian males and females, respectively * Willingness to provide written informed consent and willingness to participate and comply with the study
Exclusion criteria
* Current or recent treatment (within 6 months) with medications that influence blood glucose * Fasting blood glucose ≥ 7 mmol/L * Individuals diagnosed with type 1 or type 2 diabetes mellitus, chronic gastrointestinal disorders (including inflammatory bowel disease and celiac) or any other condition deemed unstable * Serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery * Not able to walk for 30 mins at 5-5.5 km/hr * Women planning pregnancy, pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial glucose | Three hour glucose iAUC will be calculated at nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal. | Change in glucose incremental area under the curve (iAUC) in response to a meal challenge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial insulin | Three hour insulin iAUC will be calculated at six time points (0, 30, 60, 90, 120 and 180 mins) after beginning consumption of the test meal. | Change in insulin incremental area under the curve (iAUC) in response to a meal challenge |
Outcome results
None listed