Acute Gastrointestinal Injury
Conditions
Keywords
microbiome, metabolome, biomarker
Brief summary
AGI is very common in ICU and sometimes will trigger the development of gut derived sepsis. Thus, to find out the biomarker in early stage is very important to improve the overall prognosis of critically ill patients. In this project we try to find out the microbial biomarker of AGI through multi-omic technology.
Interventions
OTHERnone intervention
none intervention.
Sponsors
Shanghai Jiao Tong University School of Medicine
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Inclusion criteria
All those critically ill patients with anticipated ICU stay for more than 2 days
Exclusion criteria
Patients will be excluded if they have any of the following situations: patients who have not signed the informed consent; Unable to tolerate intra-abdominal pressure monitoring; pregnant woman; Patients after bladder surgery; Systemic diseases and recent use of related drugs; He had a history of infectious diseases, such as tuberculosis or PPD positive. History of hypertension and poor blood pressure control (SBP / DBP \> = 140mmHg); Patients with severe mental illness; Long term use of traditional Chinese medicine, probiotics, gastric mucosal protective agents, proton pump inhibitors, chemotherapy or immunosuppressive drugs, etc. were not included if the drug was not stopped within one month before admission. \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The AUC value of the combined markers | 1 year | The combined diagnostic accuracy of AGI through omic parameters |
Countries
China
Outcome results
None listed