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Anatomic and Biomechanical Investigation on ACL: A Cadaveric Study

Anatomic and Biomechanical Investigation on Anterior Cruciate Ligament: A Cadaveric Study

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04957797
Enrollment
9
Registered
2021-07-12
Start date
2019-03-01
Completion date
2022-12-31
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Cruciate Ligament Rupture

Brief summary

The present study was aimed to investigate the kinematics differences between round-tunnel (ROT) and flat-tunnel (FLT) techniques and compare the influence to the anterior root of lateral meniscus (ARLM ) in anterior cruciate ligament (ACL) reconstruction when using hamstring graft.

Detailed description

Nine matched pairs of fresh-frozen cadaveric knees were evaluated for the kinematics of intact, ACL-sectioned, and either ROT or FLT reconstructed knees. The graft bundles for FLT technique were separately tensioned. A 6 degrees of freedom robotic system was used to assess knee laxity: (1) 134-N anterior tibial load at 0°, 15°, 30°, 60°, and 90°of knee flexion. (2) 10-Nm of valgus torque followed by 5-Nm of internal rotation torque simulates a pivot-shift test at 15°, 30°. (3) 5-Nm internal and external rotation torques at 0°, 15°, 30°, 60°, and 90°. (4) 10-Nm varus and valgus torques at 15°, 30°. Coverage of ACL tibial footprint and areas of ARLM attachment before and after reaming were measured using three-dimensional isotropic MRI scanning.

Interventions

PROCEDUREround tunnel

reamed with round tunnel

PROCEDUREflat tunnel

reamed with flat tunnel

Sponsors

Peking University Third Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)

Intervention model description

Nine matched-paired fresh frozen human cadaveric knees were randomly distributed into two groups: Flat-tunnel (FLT) group and round-tunnel (ROT) group. One knee from each pair was reamed with flat tunnel, while the contralateral knee was reamed with round tunnel.

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* intact knee with no previous injures

Exclusion criteria

* those with ligamentous injury or a limited range of motion

Design outcomes

Primary

MeasureTime frameDescription
simulated pivot-shift testwithin 1 hour after surgery10-Nm of valgus torque followed by 5-Nm of internal rotation torque simulates a pivot-shift test at 15°, 30° of knee flexion
simulated KT-2000 arthrometerwithin 1 hour after surgery134-N anterior tibial load simulates a KT-2000 arthrometer at 0°, 15°, 30°, 60°, and 90°of knee flexion
internal and external rotationwithin 1 hour after surgery5-Nm internal and external rotation torques at 0°, 15°, 30°, 60°, and 90° of knee flexion
varus and valguswithin 1 hour after surgery10-Nm varus and valgus torques at 15°, 30°of knee flexion
average percentage of ACL tibial footprint coveragewithin 1 hour after surgeryCoverage of ACL tibial footprint and areas of ARLM attachment before and after reaming were measured using three-dimensional isotropic MRI scanning post-operation

Countries

China

Contacts

Primary Contactjiahao zhang, M.D.
jiahaozhang_pkmu@163.com13001108061

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026