Bilateral Cerebral Palsy, Cerebral Palsy, Diplegic Cerebral Palsy
Conditions
Keywords
Cerebral Palsy, Bilateral Cerebral Palsy, Gait, Stepping, Stairs, Biomechanics, Neuroscience
Brief summary
The purpose of this study is to investigate lower limb impairments in children with bilateral cerebral palsy during stepping tasks.
Detailed description
Individuals with bilateral cerebral palsy (BCP) sustain a neonatal brain injury that leads to altered neuromuscular control to the lower limbs. One commonly observed motor impairment from this altered control is loss of selective voluntary motor control (SVMC), defined as the ability to independently move the joints intentionally. Loss of SVMC typically manifests as knee and ankle joint impairment and abnormal coupling between the hip adductors and lower limb extensors. This can make stepping up or down a curb or stair challenging, but quantitative investigation in these closed-chain activities has been limited. This is especially important as performance in stair-climbing is associated with limitations to overall mobility and community participation in cerebral palsy. The overall aim of this proposal is to investigate the altered neuromuscular control that challenges stair walking in individuals with BCP. Participants who consent to the study will be instructed to perform multiple step-ups and step-downs on a single raised platform. The parameters of the stepping task may change by adding weight to the body or subtracting weight from the body. Using standard gait analysis techniques, biomechanical metrics such as joint kinematics and kinetics will be analyzed.
Interventions
OTHERload modulation
Adding body weight (BW) up to 20% BW and subtracting body weight down to -20% BW
Sponsors
Northwestern University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
All participants are exposed to all conditions in a randomized order.
Eligibility
Sex/Gender
ALL
Age
5 Years to 19 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 5 years to 19 years * typically developing with no diagnosed medical conditions that affect movement, OR with a diagnosis of bilateral cerebral palsy (including diplegia, tetraplegia, and quadriplegia) where the lower limbs are more affected than the upper limbs * ability to independently step up, with or without assistive devices.
Exclusion criteria
* lower limb surgery in the past year * botulinum toxin injections to the lower limb muscles in the past 6 months * cognitive dysfunction that would make following directions difficult * comorbidities that would make participation unsafe.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Joint biomechanics (support moment) | At baseline and each loading level; During entirety of the stepping trial, from initial lift-off to final contact onto the single platform. | Sum of the joint kinetics from the hip, knee and ankle, termed the "support moment" and measured in Nm. |
| Joint biomechanics (hip) | At baseline and each loading level; During entirety of the stepping trial, from initial lift-off to final contact onto the single platform. | hip torque (measured in Nm) will be identified for the hip, knee, and ankle during the duration of the task. |
| Joint biomechanics (knee) | At baseline and each loading level; During entirety of the stepping trial, from initial lift-off to final contact onto the single platform. | Knee angle (between the thigh and shank measured in degrees) will be identified during the duration of the task. |
| Joint biomechanics (ankle) | At baseline and each loading level; During entirety of the stepping trial, from initial lift-off to final contact onto the single platform. | Ankle angle (between the shank and foot measured in degrees) will be identified during the duration of the task. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle activations (hip) | At baseline and each loading level; During entirety of the stepping trial, from initial lift-off to final contact onto the single platform. | EMG data will be identified for underlying muscles of the hip during the stance phases of the task. |
| Muscle activations (knee) | At baseline and each loading level; During entirety of the stepping trial, from initial lift-off to final contact onto the single platform. | EMG data will be identified for underlying muscles of the knee during the stance phases of the task. |
| Muscle activations (ankle) | At baseline and each loading level; During entirety of the stepping trial, from initial lift-off to final contact onto the single platform. | EMG data will be identified for underlying muscles of the ankle during the stance phases of the task. |
Countries
United States
Outcome results
None listed