Pigmented Villonodular Synovitis
Conditions
Brief summary
This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.
Detailed description
This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.
Interventions
PROCEDUREArthroscopic synovectomy
Arthroscopic synovectomy
Sponsors
Peking University Third Hospital
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Clinical diagnosis of pigmented villonodular synovitis. 2. Clinical diagnosis of giant cell tumor of tendon sheath
Exclusion criteria
1. No surgical treatment. 2. There were no pathological specimens during the operation. 3. The age of the patient is less than 18 years old or more than 60 years old. 4. The operation record shows nodular type.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group | One week after surgery | Difference of Visual Analog Score for pain between IL-1B immunohistochemistry positive group and negative group |
| Difference of scale score between immunohistochemistry positive group and negative group | One week after surgery | Difference of Visual Analog Score for pain between CSF-1 immunohistochemistry positive group and negative group |
| Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group | One week after surgery | Difference of Visual Analog Score for pain between TNF-α immunohistochemistry positive group and negative group |
| Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group | One week after surgery | Difference of SF-36 score between IL-1B immunohistochemistry positive group and negative group |
| Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group | One week after surgery | Difference of SF-36 score between CSF-1 immunohistochemistry positive group and negative group |
| Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group | One week after surgery | Difference of SF-36 score between TNF-α immunohistochemistry positive group and negative group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between basic demographic characteristics and scale scores | One week after surgery | Correlation between age, gender and scale score |
Countries
China
Outcome results
None listed