Stomach Neoplasms
Conditions
Brief summary
For prognosis evaluation, investigators enroll gastric cancer patients who underwent radical gastrectomy and collect the laboratory examination and clinicopathological characteristics. Then independent risk factors for overall survival will be analysed. For predicting efficacy evaluation, investigators also collect information of patients first diagnosed with metastases. Diagnostic efficacy is analysed by receiver operator characteristic curve method.
Detailed description
To investigate the novel predictive value of coagulation factors for postoperative outcomes after radical gastrectomy in patients with gastric cancer, investigators enroll patients with a pathologically confirmed diagnosis of gastric cancer who underwent radical gastrectomy between January 2021 and february 2017. Patients follow up data were obtained by regular follow-up. The most recent preoperative laboratory tests and clinicopathological characteristics were evaluated. Patients are devided into two groups according to our target indicator. The 5-year overall survival rate is analysed by Kaplan-Meier method. The independent risk factors for overall survival are analysed by Cox proportional hazard regression method. Investigators hypothesized that the target factor is closely related to disease progression. Whether it can be used as a tumor marker to predict metastasis is to be studied. Investigators collect laboratory examination including tumor markers of patients first diagnosed with metastases. Diagnostic efficacy is analysed and compared by receiver operator characteristic curve method.
Interventions
PROCEDUREradical gastrectomy
According to the size and location of the tumor, the appropriate surgical method was selected for radical gastrectomy
Sponsors
First Affiliated Hospital Xi'an Jiaotong University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all patients were newly diagnosed with gastric cancer; * all patients were pathologically diagnosed; * all patients had pre-treatment coagulation test; * stage I-IV disease; * age≥18 years
Exclusion criteria
* accompanying or secondary to other tumors; * had history of venous thrombosis or received any anti-coagulation treatment; * acute infection or intravascular disseminated coagulation; * pregnancy or lactation; * history of neoadjuvant chemotherapy; * Lost to follow-up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| overall survival time | From date of radical gastrectomy until the date of last follow-up or date of death from gastric cancer, whichever came first, assessed up to 48 months | From date of radical gastrectomy until the date of last follow-up or date of death from gastric cancer, whichever came first, assessed up to 48 months |
Countries
China
Outcome results
None listed