COPD
Conditions
Brief summary
Although whole body vibration (WBV) is mainly designed to promote neuromuscular function, however, because of its vibration characteristics, whether it can provide additional effects on the sputum clearance for chronic obstructive pulmonary (COPD) disease patients, thereby improving the quality of life, and exercise capacity is still unknown.
Interventions
DEVICEA vertical vibration platform PowerVibe Zen Pro 5900
Subjects received the interventions twice a week for 8 weeks. HFCWO+WBVT group received additional 30 minutes WBVT treatment. In every WBVT session, three rounds of 3 minutes of vibration (amplitude: 2 mm; frequency: 20 Hz) were provided, with a 60-second rest between rounds.
DEVICEHFCWO
Subjects received the interventions twice a week for 8 weeks. The HFCWO was delivered by a respiratory therapist using a percussive vest at 10-13 Hz oscillating frequency and at a pressure setting of 2 cm H2O. The treatment duration was 25 minutes, and the participants remained in a sitting position.
Sponsors
Kaohsiung Medical University Chung-Ho Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
35 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Confirmed diagnosis of COPD at the outpatient thoracic medicine clinic * Need HFCWO as judged by the doctor
Exclusion criteria
* Acute COPD exacerbation within the previous 4 weeks, * Contraindication for WBVT (e.g., artificial joint replacement, a history of deep vein thrombosis, or known aortic aneurysm) * Inability to perform squatting exercises * Acute disc disease * Inability to complete the 6MWT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| FEV1 | 8 weeks | forced expiratory volume in 1 second in pulmonary function test (Liters) |
| 1 min STST | 8 weeks | the number of repetitions performed in the 1-min sit-to-stand test (rep.) |
| 5-rep STST | 8 weeks | the complete time for the 5-repetition sit-to-stand test (sec) |
| FEV1/FVC | 8 weeks | forced expiratory volume in 1 second divided by forced vital capacity in pulmonary function test (%) |
| FVC(% pred) | 8 weeks | percentage of predicted FVC value (% pred) |
| FEV1(% pred) | 8 weeks | percentage of predicted FEV1 value (% pred) |
| 6 min walk distance | 8 weeks | the distance walked in 6 minutes (m) |
| Predicted distance | 8 weeks | percentage of the predicted 6 minute walk test distance (%pred) |
| Distance-Saturation Product (DSP) | 8 weeks | the product of distance walked and lowest oxygen saturation during the 6-min walk test (m%) |
| FVC | 8 weeks | forced vital capacity tested in pulmonary function test (Liters) |
| Muscle strength test1 | 8 weeks | Maximal force output for biceps femoris muscle (lbs) |
| Muscle strength test2 | 8 weeks | maximal force output for quadriceps muscle (lbs) |
| Sputum self-assessment scale | 8 weeks | questionnaire of sputum volume, it contained three items (0-25 mL/d, 25-50 mL/d, and 50-100 mL/d) as a checklist |
| X-ray score | 8 weeks | the evaluation of the chest radiography based on the sputum impaction score, scores ranging from 0 to 18. A decrease in score represented an improvement in sputum in each area. |
| modified Medical Research Council (mMRC) | 8 weeks | questionnaire of dyspnea, scores ranging from 0 (low degree of dyspnea) to 4 (high degree of dyspnea) |
| chronic obstructive pulmonary disease assessment test (CAT) | 8 weeks | questionnaire of COPD symptoms, scores ranging from 0 to 40, higher scores indicating more severe impact of COPD on their life |
| Saint George Respiratory Questionnaire (SGRQ) | 8 weeks | questionnaire of overall health, daily life, and perceived well-being, scores ranging from 0 (no health impairment) to 100 (maximum health impairment) |
Countries
Taiwan
Outcome results
None listed