The Efficacy and Safety of the Loading Dose of Tranexamic Acid in Scoliosis Surgery During Perioperative

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04952285

Enrollment

207

Registered

2021-07-07

Start date

2015-01-01

Completion date

2017-12-31

Last updated

2021-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tranexamic Acid

Keywords

tranexamic acid, Blood conservation

Brief summary

This study intends to make full use of the advantage of spinal orthopedic surgery in our medical center.Analyze the blood loss and blood coagulation function and the influence of safety of load dose tranexamic acid (TXA) in scoliosis surgery during perioperative.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* age:18-60 years old * American Society of Anesthesiologists (ASA):I-II * The spinal orthopedic undergoing elective surgery

Exclusion criteria

* Severe cardiopulmonary dysfunction * Blood coagulation dysfunction * Disorders of liver and kidney function * Tranexamic acid allergies * The history of pulmonary embolism and venous thrombosis of lower limbs * Anticoagulant drugs and nonsteroidal anti-inflammatory drugs in 7 days

Design outcomes

Primary

Measure	Time frame	Description
Incision drainage Incision drainage Incision drainage after surgery	24 hours after surgery	Incision drainage after surgery
Intraoperative blood loss	At the end of the surgery	Intraoperative blood loss

Secondary

Measure	Time frame	Description
Plasma infusion	At the end of the surgery	Plasma infusion
HB	Within 1 week before surgery；1 day after surgery	hemoglobin
WBC	Within 1 week before surgery；1 day after surgery	White blood cells
Autologous blood doping	At the end of the surgery	Recycle the blood during the intraoperative , back to the patient
PT	Within 1 week before surgery；1 day after surgery	Prothrombin time
APTT	Within 1 week before surgery；1 day after surgery	activated partial thromboplastin time
INR	Within 1 week before surgery；1 day after surgery	International Normalized Ratio
PTL	Within 1 week before surgery；1 day after surgery	platelet
red blood cell transfusion	At the end of the surgery	red blood cell transfusion

Outcome results