Amyotrophic Lateral Sclerosis
Conditions
Brief summary
200 cases of ALS patients were collected to explore whether sleep disorders are related to earlier onset age, and whether sleep disorders accelerate the progress of ALS and shorten the survival time of ALS patients.
Detailed description
200 patients with ALS were collected. 1) sleep disorders were assessed by Pittsburgh sleep quality index (PSQI) and Epworth Sleepiness Scale (epworth) at baseline Sleeping Scale，ESS）； 2) Name, age, gender and onset site were collected to explore whether sleep disorders were associated with earlier onset age; 3) The patients' function (ALSFRS-R) at baseline and every 3 months within 2 years were collected, and the end-point time (death and invasive breathing) was recorded to evaluate whether sleep disturbance accelerated the decline of patients' function and shortened their short-term survival.
Interventions
BEHAVIORALsleep disorder
ALS patients with or without sleep disorder
Sponsors
Peking University Third Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients who have been diagnosed in the Department of Neurology of the Third Hospital of Beijing Medical University since August 2020. The clinical diagnosis of patients with amyotrophic lateral sclerosis includes: probable and define; * Informed consent has been signed.
Exclusion criteria
* Those who can not cooperate to complete the scale and receive follow-up.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ALSFERS-R | 2 years | ALS functional score |
| end point event | 2 years | death or invasive breathing |
Countries
China
Contacts
Primary ContactDongsheng Fan
Outcome results
None listed