Amyotrophic Lateral Sclerosis
Conditions
Brief summary
Using the original MRI images of 16 ALS patients and 16 normal controls matched by gender, age and education level in the previous study, the differences of brain volume in different parts of ALS patients and normal controls, and the correlation between brain structure and clinical characteristics were compared by precise brain volume quantitative analysis technology.
Detailed description
This study was a retrospective study. The subjects were 16 ALS patients and 16 normal controls. Previous studies have collected patients' age, gender and education level; The onset site, onset time, bulbar involvement, diagnostic grade, ALSFRS-R score, application of ventilator, application of lirutai, gastrostomy; Age, gender and education level were collected in the control group. Accurate quantitative analysis of brain volume was performed on the original brain MRI images of the two groups.
Interventions
DIAGNOSTIC_TESTDiagnostic criteria
Diagnostic criteria of ALS
Sponsors
Chinese University of Hong Kong
Peking University Third Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Inclusion criteria
* Diagnosed ALS patients * healthy volunteers
Exclusion criteria
* none
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Accurate quantitative analysis of brain volume | 1 day | Accurate quantitative analysis of brain volume using magnetic resonance brain imaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| general situation | 1 day | Age, gender and education level were collected; Onset site, onset time, involvement of bulbar, diagnostic grade, ALSFRS-R score, application of ventilator, application of lirutai, gastrostomy |
Countries
China
Outcome results
None listed