Pregnancy Related
Conditions
Keywords
Pregnancy, Tomography, Optical Coherence, Choroid, retina
Brief summary
During pregnancy many physiological changes and adaptations occur.Hormonal, hematological and hemodynamic changes are responsible for most of the ocular adaptations.We are planning to compare the choroid and retinal blood flow values and choroidal thickness of pregnant women and healthy non pregnant women with optical coherence tomography and optic coherence tomography angiography
Detailed description
During pregnancy many physiological changes and adaptations occur such as pulmonary, renal, endocrinological, haematological and visual system changes are happening. In previous studies, retinal and choroidal pregnancy-related changes in blood flow and choroidal thickness have been demonstrated. Optical coherence tomography angiography (OCTA) detects the contrast of motion in the blood flow, detecting the capillary of the retina and choroid. It is a new functional method that visualizes the retinal networks and outer retina without using dyes.It is a non-invasive method that provides volumetric angiography information. In this study evaluation of the variability of choroidal and retinal blood flow changes and choroidal thickness, between trimesters of pregnancy and the non-pregnant control group is planned. Choroid and Retinal Blood Flow Values and Choroidal thickness in 41 pregnant women in the first trimester and it would be repeated at second and third trimesters. We compare measured values between trimesters and 45 healthy non-pregnant women.
Interventions
DIAGNOSTIC_TESTOptical Coherence Tomography,Optical Coherence Tomography Angiography(Topcon)
Optical coherence tomography optical coherence tomography angiography
Sponsors
Akdeniz University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy pregnant women Age \> 18 years
Exclusion criteria
* Systemical disease such as diabetes mellitus or hypertension * Refractive error; spherical equivalence \> 4 diopters * Ocular disease or surgery history
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Retinal thickness | 40 weeks | Retinal thickness is measured by optical coherence tomography |
| Choroidal thickness | 40 weeks | Choroidal thickness is measured by optical coherence tomography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Foveal avascular zone(FAZ) area measurement | 40 weeks | FAZ area is measured by optical coherence tomography anjiography |
| Retinal vascular density | 40 weeks | % of retinal vascular density is measured by optical coherence tomography angiography |
| Retinal nerve fiber layer thickness | 40 weeks | Retinal nerve fiber layer thickness (um) is measured by optical coherence tomography |
| Ganglion cell layer measurement | 40 weeks | Ganglion cell layer measurement is measured by optical coherence tomography |
Countries
Turkey (Türkiye)
Outcome results
None listed