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Comparison of AOCT and AOPT for the Treatment of Medial Large Cystic OLT

Comparison of Autologous Osteoperiosteal and Osteochondral Transplantation for the Treatment of Medial Large Cystic Osteochondral Lesions of the Talus

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04950335
Enrollment
46
Registered
2021-07-06
Start date
2014-03-01
Completion date
2020-11-10
Last updated
2021-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteochondral Lesions of the Talus

Brief summary

Autologous osteoperiosteal transplantation using tissue harvested from the iliac crest is used to treat large cystic osteochondral lesions of the talus. This study is to compare clinical and radiological outcomes between patients undergoing AOPT and those undergoing AOCT for large cystic OLTs.

Detailed description

From March 2015 to March 2018, 23 patients who underwent AOPT and 23 patients who underwent AOCT to treat large cystic OLTs (\>10mm) were retrospectively evaluated. For comparability, the two groups were matched based on their demographics, including sex, age, body mass index, side of injury, follow-up period, and the preoperative cyst volume. Clinical outcomes were assessed using the visual analog scale (VAS), the American Orthopaedic Foot & Ankle Society (AOFAS) score, and the Tegner score. Donor-site morbidity was recorded according to the symptoms, including pain, stiffness, swelling and discomfort. Radiological outcomes were evaluated using the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score, and the International Cartilage Repair Society (ICRS) score was obtained during second-look surgery.

Interventions

PROCEDUREAOPT

The Osteochondral Autograft Transplant System (Arthrex) was used to create donor plugs. Osteoperiosteal grafts were harvested from the ipsilateral anterior superior iliac spine.

PROCEDUREAOCT

Osteochondral grafts were harvested from the non-weight-bearing zone of the ipsilateral anterolateral distal femur.

Sponsors

Peking University Third Hospital
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* presence of medial large cystic OLTs (\>10 mm in diameter) confirmed by preoperative magnetic resonance imaging (MRI) * patients who underwent either primary AOPT or AOCT

Exclusion criteria

* small cystic OLTs * ankle osteoarthritis * ankle pigmented villonodular synovitis * prior surgery on the ipsilateral ankle * injuries or relevant trauma to the affected ankle after surgery

Design outcomes

Primary

MeasureTime frameDescription
MOCARTtwo years after sugerythe Magnetic Resonance Observation of Cartilage Repair Tissue score

Secondary

MeasureTime frameDescription
VASpre-surgery, two years after sugerythe visual analog scale
Tegnerpre-surgery, two years after sugerythe Tegner score
AOFASpre-surgery, two years after sugeryAmerican Orthopaedic Foot & Ankle Society score
ICRSone year after sugerythe International Cartilage Repair Society score

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026