Postoperative Cognitive Dysfunction, Sevoflurane, Carotid Artery Intima Stripped
Conditions
Brief summary
Brief summary: In order to get a better clinical plan for brain protection during perioperative anesthesia for high-risk patients - carotid intima stripped. We observing the hemodynamic changes of sevoflurane post-treatment in carotid intima stripped, the comparison of postoperative cognitive function and postoperative radiographic changes.
Interventions
propofol plus 1% sevoflurane after open Carotid artery until the end of surgery
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anesthesiologists（ASA）：II-III * Aged between 40 and 80 years * Patients scheduled for surgery of Carotid stenosis under general anaesthesia
Exclusion criteria
* Has a history of mental illness can't cooperate, * Serious heart block or cardiac decompensation or severe sinus slow (HR \< 50 times/min), * The abnormal nerve monitoring in operation, MMES preoperative score \< 20 points, * Any rescue unexpected occurred during the operation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from the 1 day preoperative to the 1 day postoperative MMSE(Mini-mental State Examination) | the 1st day before the surgery；the 1st day after the surgery | Screening scale of cognitive function。The highest score is 30 points, 27 to 30 were divided into normal, less than 27 divided into cognitive dysfunction。But is not sensitive in the early identification of dementia, especially in mild cognitive impairment is poorer. |
| Change from the 1 day preoperative to the 1 day postoperative MoCA(Montreal Cognitive Assessment) | Time Frame: the 1st day before the surgery；the 1st day after the surgery | Screening scale of cognitive function。The highest score is 30 points，Add 1 score, education the following subjects in less than 12 years。Total score less than 26 divided into cognitive dysfunction。Compared with MMSE, more sensitive to mild dementia。 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BIS | Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4） | bispectral index |
| Heart rate | Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4） | Heart rate per minute |
| Cerebral oxygen saturation | Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4） | Cerebral oxygen saturation |
| PETCO2 | Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4） | Partial pressure End-Tidal Carbon Dioxide |
| Invasive arterial blood pressure | Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4） | Invasive arterial puncture catheter, continuous arterial pressure monitoring |
Countries
China
Contacts
Primary ContactWang Bin, master
Outcome results
None listed