Adrenal Disease
Conditions
Brief summary
The aim of this study is to develop a one-step diagnostic method for adrenal diseases, Patients with adrenal diseases including non-functioning adrenal adenoma, adrenal Cushing's syndrome, primary aldosteronism, and pheochromocytoma will be recruited. Using mass spectrometry analysis based on a multisteroid panel, serum, urine, saliva, and hair samples of the patients will be analyzed. The diagnostic yield of each and combination of steroids will be evaluated.
Detailed description
Adrenal diseases consist of heterogenous diseases. To differentiate various adrenal diseases, multiple steps of diagnostic tests are needed. In this study, the investigators aimed to develop a one-step diagnostic method to differentiate various adrenal diseases using multisteroid panel. About 400 patients with adrenal diseases including non-functioning adenoma, adrenal Cushing's syndrome, primary aldosteronism, and pheochromocytoma will be recruited. Serum, hair, saliva, and urine samples of the patients will be analyzed using mass spectrometry. Each and combination of multisteroid will be evaluated for diagnosing adrenal diseases.
Interventions
None listed
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who are diagnosed with adrenal diseases
Exclusion criteria
* Taking medications that can affect steroid metabolism * Major depression, chronic alcoholism * Suspected cancer metastasis to adrenal glands * Other acute stress conditions
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of multisteroid panel for differentiating adrenal diseases | Within 1 year after subject recruitment when the final diagnosis of adrenal diseases are made | * Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of Cushing's syndrome. * Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of primary aldosteronism. * Evaluate how accurately the developed multisteroid panel diagnoses adrenal disease by measuring sensitivity (%) and specificity (%) for diagnosis of pheochromocytoma. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic accuracy of each steroid component for differentiating adrenal diseases | Within 1 year after subject recruitment when the final diagnosis of adrenal diseases are made | Evaluate how accurately each component of the steroid panel differentiate adrenal diseases. * Sensitivity (%) and specificity (%) of each steroid measures for adrenal Cushing's syndrome will be calculated. * Sensitivity (%) and specificity (%) of each steroid measures for primary aldosteronism will be calculated. * Sensitivity (%) and specificity (%) of each steroid measures for pheochromocytoma will be calculated. |
Countries
South Korea
Outcome results
None listed