Cognitive Dysfunction, Hypotension; Controlled
Conditions
Keywords
cerebral oxygenation, cognitive function, esmolol, nitroglycerine
Brief summary
The present study aimed to assess the influence of nitroglycerin and esmolol-induced hypotension on cerebral oxygen saturation by using near-infrared spectroscopy and postoperative cognitive function in patients undergoing nasal surgery.
Interventions
DRUGEsmolol
DRUGNitroglycerin
Sponsors
Zonguldak Bulent Ecevit University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* written informed consent * patients with ASA physical status of I-II * aged 18-65 years
Exclusion criteria
* Age under 18 or above 65 * ASA \> II * coagulation disorders * history of cardiovascular and cerebrovascular disease * poor Blood Pressure control * anemia, pregnancy, addiction to opioids * body mass index (BMI) \> 35 * intraoperative systolic BP \< 65 mmHg * surgical duration less than 30 minutes or more than 160 minutes * need for an intraoperative sympathomimetic drug and the use of other hypotensive drugs * preoperative Mini-Mental State Examination (MMSE) score of 23 or less.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| effects of controlled hypotension on cerebral oxygen saturation | until end of the surgical procedure. | influence of nitroglycerin and esmolol-induced hypotension on cerebral oxygen saturation by measuring regional cerebral oxygen saturation using Near-Infrared Spectroscopy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| effects of controlled hypotension on cognitive function | 24 hour before surgery and 24 hour after surgery | influence of nitroglycerin and esmolol-induced hypotension on postoperative cognitive function using mini mental test score |
Countries
Turkey (Türkiye)
Outcome results
None listed