Kidney Diseases
Conditions
Brief summary
The estimates risks and benefits of the percutaneous kidney biopsy have been reported mainly from retrospective studies. So far no prospective multicentre studies has been designed to identify rates of biopsy related complications. The aim of this prospective multicentre study was to evaluate safety and complication events related to biopsies on native kidney in Italy.
Detailed description
Kidney biopsies performed in 54 italian nephrology centres from 2012 to 2020 were included. Primary outcome of the study was any major complication, such as haemoglobin decrease more than 2 g/dL, macroematuria, gross ematoma, blood transfusion, artero-venous fistula, invasive intervention, pain, symptomatic hypotension, and/or rapid serum creatinine increase. Centre and individual patient risk predictors were analysed using multivariate logistic regression analysis.
Interventions
PROCEDURENative kidney biopsy
Sponsors
Simeone Andrulli, MD
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* adult or pediatric patients with a kidney disease * informed Consent
Exclusion criteria
* patient with a transplanted kidney
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Any major post-biopsy complication event | one week follow-up after native kidney biopsy | The cecked of major post-biopsy complication events were clinically relevant hematomas, macrohematuria, decrease of haemoglobin levels after 24 hours \> 2 g /dL, the need for blood transfusion, a large and persistent AV fistula, a post-biopsy anuria, an increase in serum creatinine greater than 50% in the week following biopsy, the need for invasive post-biopsy procedure related to the procedure including nephrectomy, the death related to biopsy |
Countries
Italy
Outcome results
None listed