Bowel Preparation, Colonic Adenoma
Conditions
Keywords
bowel preparation, Oral magnesium sulfate solution, polyethylene glycol solution
Brief summary
Adequate bowel preparation is critical for successful colonoscopy and a large volume of PEG was required for bowel preparation in patients undergoing colonoscopy. The investigators conducted a a prospective, randomized, controlled study to compare low dose of oral magnesium sulfate solution with high dose PEG. The investigators found that patients who took low dose of oral magnesium sulfate solution had similar bowel preparation quality to patients who took PEG,but accompanied with fewer adverse events and better tolerance.
Interventions
OTHERsplit-dose of Magnesium Sulfate solution
purgative for bowel preparation
OTHERsplit-dose of PEG
purgative for bowel preparation
Sponsors
Air Force Military Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* patients who underwent colonoscopy
Exclusion criteria
* known or suspected bowel stricture or obstruction; * history of colorectal surgery; * significant gastroparesis or gastric outlet obstruction; * toxic colitis or megacolon; * severe acute inflammatory bowel disease; * active gastrointestinal bleeding; * suspected or confirmed chronic renal insufficiency and heart illness; * disturbance of electrolytes ; * unable to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The rate of patients with adequate bowel preparation | 1 year | Defined by each segmental BBPS≥2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The rate of adenoma detection | 1 year | The proportion of participants with at least one adenoma in each group |
| the numbers of patients with adverse events | 1 year | eg. Vomiting, nausea, abdominal pain |
| The cecal intubation rate | 1 year | The rate of colonoscopy reaching the cecum |
| The time of Cecal intubation | during procedure | the time between the intubation and visualization of any of the following anatomic landmarks: ileocecal valve, appendiceal orifice, or terminal ileum |
| the time during Withdrawal phage | during procedure | the inspection time from cecum to rectum |
Countries
China
Outcome results
None listed