COVID-19 Respiratory Infection
Conditions
Brief summary
rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins. These pleiotropic cytokines are secreted at the region of inflammation and released into the circulation by a variety of different cell types, including macrophages, lymphocytes, endothelial cells, epithelial cells during sepsis and acute organ injuries. There has recently found a number of studies reporting that the cytokine storms take part in the course of COVID-19
Detailed description
Aim Of The Study 1. To evaluate if there is an association between the IL-17, IL-23 gene polymorphism in Patients With COVID 19 by real-time PCR 2. To measure the serum level of IL17 by ELISA in COVID 19 patients by ELISA. 3. To detect if there is an association between gene polymorphism of IL17 and IL23 and severity of a condition in patients with COVID 19 Study design: a cross-sectional study. The blood samples will be collected from patient records in COVID19 isolation hospitals in sohag governorate and isolation department in sohag university hospitals.
Interventions
DIAGNOSTIC_TESTlaboratory test
genotyping of IL 17 and IL23
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with Covid19 positive PCR
Exclusion criteria
* Patients with Covid19 clinical criteria not confirmed by PCR
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| genotyping of IL 17 | 3-6-2021 to 30-8-2021 | real time pcr detection of different genotypes |
| genotyping of IL 23 | 3-6-2021 to 30-8-2021 | real time pcr detection of different genotypes |
| estimation of serum level of IL 17 | 3-6-2021 to 30-8-2021 | measuring serum level of IL 17 by ELISA |
Countries
Egypt
Outcome results
None listed