Circulating Epigenetics in Pancreatic Surgery

Towards Precision Medicine in Pancreatic Surgery - an Integrative Approach Combining Deep Learning, Genetics and Epigenetics

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04947696

Enrollment

200

Registered

2021-07-01

Start date

2021-07-30

Completion date

2023-07-01

Last updated

2021-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic Neoplasms

Brief summary

The overall objective of the study is to assess DNA-methylation changes in circulating blood cells and cell free DNA in plasma from patients undergoing the Whipples procedure for pancreatic caner

Interventions

DIAGNOSTIC_TESTBlood sampling

Blood sampling preoperatively and sequentially up to 30 days post op

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with pancreatic cancer scheduled for the Whipples procedure

Exclusion criteria

* Under 18 years of age * Pregnancy * Unable to provide informed consent.

Design outcomes

Primary

Measure	Time frame
Changes in DNA-methylation patterns from the pre to postoperative setting	Up to 30 days postoperatively

Secondary

Measure	Time frame
Occurence of a postoperative complication	30 days postoperatively
Relapse of pancreatic cancer	2 years from time of operation

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026