Microtia
Conditions
Brief summary
The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
Detailed description
The study conforms to a randomized, single-blinded, placebo-controlled parallel study design. a prebiotic supplement will be selected based on a participants gut microbiota. 1 sachet of prebiotic or placebo will be given twice a day over a period of 6 weeks. Before the start of the study, a VO2max test will be performed. Subjects will bring faecal samples which is collected at home. A time to exhaustion of approximately 80% of their VO2max will be performed at baseline and after the 6 weeks intervention period.
Interventions
DIETARY_SUPPLEMENTPrebiotic
6 weeks of prebiotic supplementation twice a day
OTHERPlacebo
6 weeks of maltodextrin supplementation twice a day
Sponsors
Maastricht University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Intervention model description
The study conforms to a randomized, single-blinded, placebo-controlled parallel study design.
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female 18 - 40 y * BMI range 18.5 - 25 kg/m2 * Recreational active (performing non-competitive physical endurance exercise at least two times per week with a minimum duration of 60 minutes per exercise bout)
Exclusion criteria
* Smoking * Performing regular resistance training (3+ times per week, carrying out progressive overload training) * Subject following an overly imbalanced or restrictive diet as per nutritional advice * Participants who received antibiotics in the 90 days prior to the start of the study * Self-admitted lactose intolerance * Administration of probiotic or prebiotic supplements in the 14 days prior to the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to Exhaustion | From baseline to end of the study (up to max 45 days) | Time on cycle ergometer until exhaustion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gut microbiota composition | From baseline to end of the study (up to max 45 days) | Composition of the gut microbiota by faecal sample analysis |
| Plasma short chain fatty acids | From baseline to end of the study (up to max 45 days) | Short chain fatty acids in plasma |
| Blood glucose | From baseline to end of the study (up to max 45 days) | Fasted blood glucose |
| Insulin | From baseline to end of the study (up to max 45 days) | Fasted insulin |
| Intestinal permeability by sugar test | From baseline to end of the study (up to max 45 days) | Intestinal permeability measured by a sugar drink test |
Countries
Netherlands
Contacts
Primary ContactFreddy Troost, Dr.
Outcome results
None listed