Knee Osteoarthritis
Conditions
Brief summary
This pilot study aims to assess the effect of a 6-week individualized gait retraining program on knee load and symptoms in persons with knee osteoarthritis (OA).
Detailed description
This study aims to pilot-test an individualized gait retraining intervention to reduce knee load, guided by real-time visual feedback of the external knee adduction moment (KAM), a commonly used determinant for medial tibiofemoral (TF) joint load, during walking. Our central hypothesis is that individuals with predominantly medial TF OA can adapt their gait patterns to lower KAM during walking; consequently, reduce knee load and pain.
Interventions
OTHERGait modification
Individualized gait modifications guided by real-time visual feedback of knee load
Sponsors
Northwestern University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
This is a pilot single-arm study examining the effect of an intervention on biomechanical and symptomatic outcomes. There is no control group, therefore no masking employed.
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* people with radiographic TF OA fulfilling American College of Rheumatology classification criteria * reporting average knee pain on walking \> 3 on an 11-point scale (0-10) in at least one knee * pain or tenderness predominantly located on the medial knee.
Exclusion criteria
* medial TF joint space width greater than lateral * Kellgren/Lawrence (K/L) grade 4 * knee surgery or intra-articular corticosteroid injection in the past 6 months * uncomfortable walking on treadmill for 20 minutes * unable to walk without a walking aide * inflammatory arthritis * other musculoskeletal or neurological disorders that affect gait patterns * currently receiving physical therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| External knee adduction moment during walking | Baseline-to-6-week change | The external knee adduction moment during walking will be assessed using a10-camera optical motion capture system and force plates. A visual 3D program will be used to compute and plot the pre- and post-intervention external knee adduction moment during walking. |
| WOMAC (Western Ontario and McMaster Universities) score | Baseline-to-6-week change | WOMAC questionnaire contains 24 questions in three domains of pain (score range 0-20), stiffness (score range 0-8) and physical function (score range 0-68). Higher score indicates worse symptom/function. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| External knee flexion moment during walking | Baseline-to-6-week change | The external knee flexion moment during walking will be assessed using a10-camera optical motion capture system and force plates. A visual 3D program will be used to compute and plot the pre- and post-intervention external knee flexion moment during walking. |
| KOOS (Knee Injury and Osteoarthritis Outcome Score) | Baseline-to-6-week change | KOOS questionnaire contains 42 items in 5 domains of pain, other symptoms, function in daily living, function in sport and recreation, and knee-related quality of life. Scores are transformed to a 0-100 scale, with 0 representing extreme knee problems and 100 representing no problems. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORAlison H Chang
Northwestern University
Outcome results
None listed