Covid19, Vitamin D Deficiency
Conditions
Keywords
COVID-19, Vitamin D, Disease severity, Inflammatory markers
Brief summary
Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.
Detailed description
In this retrospective study 300 patients diagnosed with COVID19 were included. According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3). The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal. Patients' age, gender, comorbid diseases and laboratory values were recorded
Interventions
DIAGNOSTIC_TESTInflammatory Parameters
Laboratory measurement of patient's inflammatory status in unit of % and mg/dl
OTHER25 OH Vitamin D Level
Laboratory measurement of patient's 25 OH vitamin D level in unit of ng/dl
Sponsors
Fatih Sultan Mehmet Training and Research Hospital
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 97 Years
Inclusion criteria
* The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months
Exclusion criteria
* Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 25-OH vitamin D | 1 day | laboratory measurement in unit of ng/ml |
| White blood cell count | 1 day | laboratory measurement in unit of x103/uL |
| neutrophil count | 1 day | laboratory measurement in unit of x103/uL |
| neutrophil ratio | 1 day | laboratory measurement in unit of % |
| lymphocyte count | 1 day | x103/uL |
| lymphocyte ratio | 1 day | laboratory measurement in unit of % |
| platelet count | 1 day | laboratory measurement in unit of x103/uL |
| hemoglobin count | 1 day | laboratory measurement in unit of g/dl |
| C-reactive protein levels | 1 day | laboratory measurement in unit of mg/dL |
| neutrophil to lymphocyte ratio | 1 day | laboratory measurement in unit of % |
| platelet to lymphocyte ratio | 1 day | laboratory measurement in unit of % |
Countries
Turkey (Türkiye)
Outcome results
None listed