Analgesia, Osteosarcoma
Conditions
Keywords
epidural analgesia, lower extremity osteosarcoma
Brief summary
In this study, the investigators aim to reduce complications in orthopedic malignancy surgeries and to increase the quality of life of patients who will be operated on.
Detailed description
In the preoperative period, the participants will be taken to the block room. The participants will be monitored, standard sedation will be applied. Patients in the first group will be provided with preoperative and peroperative analgesia with an epidural catheter. The second group patient will be get no block. Afterwards, both groups will be operated under similar general anesthesia conditions. A patient-controlled analgesia device will be attached to each group of participants and their postoperative follow-up will be made.
Interventions
PROCEDUREEpidural Analgesia
In the anesthesia preparation room, an epidutal catheter will be placed with a toue needle through the L4-5 spinal space. After induction of general anesthesia, 10 ml of 0.25% bupivacaine will be injected through the epidural catheter.Afterwards, peroperative and postoperative analgesia will be provided with epidural PCA.
Sponsors
Istanbul University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Study group and control group
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* accepting the study protocol, * age older than 18 years and younger than 80 years, * undergoing lower extremity osteosarcoma surgery * the American Society of Anesthesiologist (ASA) physical status of I-II-III
Exclusion criteria
* infection at the injection site * coagulation disorder * patients with central nervous system related disease * septic patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Opioid consumption | 48 hours | miligram |
| Measurement of postoperative pain | 48 hours | VAS (visual analog scale) (0: no pain, 10: the worst pain imaginable) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative complications | postoperative period up to 3 days | yes/no |
| Intensive care unit stay | 48 hours | hours |
| Amount of peroperative bleeding | During surgery | Mililiter |
| Patient satisfaction | Will be done 3 times 1- a day after surgery 2- in the 1st week follow up after surgery 3- in the 1st month follow-up after surgery | 5-point Likert scale: very satisfied (= 5), satisfied (= 4), neutral (= 3), dissatisfied (= 2) and very dissatisfied (= 1) |
| Beck Depression Inventory (BDI) | Will be done 2 times 1- on pre-operative hospitalization 2- in the 1st month follow-up after surgery] | 0-9: indicates minimal depression 10-18: indicates mild depression 19-29: indicates moderate depression 30-63: indicates severe depression |
| Hospital stay | 72 hours | hours |
| Amount of postoperative bleeding | 48 Hours | Mililiter |
Countries
Turkey (Türkiye)
Contacts
Primary ContactNur Canbolat, MD
Backup ContactMehmet Büget, Assoc. Prof.
Outcome results
None listed