Magnetic Resonance Imaging
Conditions
Keywords
dynamic glucose enhanced, human brain tumor, chemical exchange saturation transfer
Brief summary
Recently, natural D-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using D-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. Our study try to evaluate the feasibility of dynamic glucose enhanced(DGE) magnetic resonance imaging（MRI）in brain tumor, which based on D-glucose weighted chemical exchange saturation transfer (gluceoCEST).
Detailed description
methods： Brain tumor patients were recruited. Time-resolved glucose signal changes were detected using chemical exchange saturation transfer (glucoCEST) MRI. Dynamic glucose enhanced (DGE) MRI was used to measure tissue response to an intravenous bolus of D-glucose. During the dynamic glucose scan, a brief hyperglycemic state was established by intravenous infusion of hospital-grade D50 glucose (D50, 25 g of dextrose in 50 mL of water sterile solution), followed by 20 mL of saline solution in 1 arm. The glucose infusion was performed using a power injector at an infusion rate of 0.2 mL/s, corresponding to total infusion times of 250 seconds. Performing contrast enhancement based on Gd-DTPA in 30 minutes later, which was used for comparison as golden standard. The area of hyperintensity will be measured, which represents the area of brain tumor. Differential test and Consistency analysis were used for statistical analysis.
Interventions
DRUGd-glucose
using d-glucose as an contrast agent on CEST MR Imaging
Sponsors
Zhujiang Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patient must have a brain mass consistent with a primary brain tumor or metastatic brain tumor * able to give consent and willingness to participate in this study.
Exclusion criteria
* presence of any ferromagnetic implant (cardiac pacemakers, aneurysm clip, etc.) * pregnancy * claustrophobia or anxiety disorder * history of vertigo * persons with diabetes mellitus (self-report or HbA1C \>= 6.5%) * Sickle cell disease * persons taking prescription medicine for hypertension * blood iron deficiency (Hb concentration \< 11 g/dL or Hct \< 32%) * If volunteering for MRI: history of kidney disease and/or eGFR \< 60. * Middle-ear disorder * double vision * Seizure disorder * Multiple myeloma * Solid organ transplant * History of severe hepatic disease/liver transplant/pending liver transplant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CEST value of tumor lesion including tumor core/ necrosis/ cysis/ edema | 1 week | the CEST value of tumor core and necrosis might higher than white matter |
Countries
China
Contacts
Primary ContactZhibo Wen, PhD
Backup ContactJianhua Mo, MD
Outcome results
None listed