Functional Neurological Disorder
Conditions
Brief summary
The purpose of this study is to better understand Functional Neurological Disorders (FND) by measuring movement timing and brain activity in patients with FND during deliberate movements and when expressing an 'intention' to move. This investigation will use non-invasive brain stimulation to investigate the role of the temporal-occipital-parietal junction in FND.
Detailed description
This study seeks to improve our neurophysiological understanding of Functional Neurological Disorders (FND) by measuring movement timing and brain activity while individuals with FND perform a simple pointing task. Behavioural (timing of arm and finger movement) and electrophysiological (electroencephalography; EEG) measures will be collected both at rest and while participants perform a voluntary movement task designed to discriminate between brain events related to intention vs. overt action. Furthermore, this study will investigate the ability of a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to alter brain activity in the temporal-occipital-parietal junction (TPJ), a region known to be hypo-active in individuals with FND. Tasks and cortical recordings will be repeated following rTMS to determine the effect of brain stimulation on behaviour and brain activity.
Interventions
A non-invasive method of brain stimulation
Sponsors
University of Winnipeg
University of Manitoba
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Confirmed diagnosis of Functional Neurological Disorder with motor symptoms.
Exclusion criteria
* Presence of another comorbid psychiatric disorder; * Any contraindication for rTMS (e.g., implanted metal devices; cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps, metal in the body \[rods, plates, screws, shrapnel, dentures, IUD\] or metallic particles in the body, surgical clips in the head, previous neurosurgery, cochlear implants, prosthetic heart valves); * Currently pregnant.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in relative timing of intention-to-act vs action production | 1 hour: Immediately prior to and following one session of rTMS | Assessment of change in the lag time between intended and actual action production during pointing and stimulus response tasks. |
| Change in resting state activity in temporal-parietal junction brain region | 1 hour: Immediately prior to and following one session of rTMS | Assessment of changes in EEG brain activity readings when participants are at rest at various frequencies, primarily targeting delta/theta bands. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in brain activity related to 'intention to act' | 1 hour: Immediately prior to and following one session of rTMS | Assessment of changes in ERP waveform amplitude related to the 'intention to act' time-stamp during the movement task. |
| Change in brain activity related to motor production | 1 hour: Immediately prior to and following one session of rTMS | Assessment of changes in ERP waveform amplitude related to the 'motor production' time-stamp during the movement task. |
Countries
Canada
Outcome results
None listed