Cardiac Output
Conditions
Keywords
Total-body; PET/CT; N-13 ammonia; Blood perfusion
Brief summary
The aim of our study is to analyze and quantitate whole-body blood perfusion by total-body 13N-NH3 PET/CT(uEXPLORER), and evaluate the influence to other organs in severe AS patients and the impact of TAVR surgery.
Detailed description
Participants are invited to participate in a research that seeks to understand the dynamic blood perfusion in severe AS patients in human body. The investigators expect to have twenty-five participants in this study at Renji Hospital, Shanghai. Nine participants will be healthy individuals with no known vascular disease. All the participants will undergo the same procedure. If participants agree to participate in this study, researchers will first interview participants and review the past medical record in order to document the medical history. When the screening procedures confirm that participants are eligible to participate in the study, participants will receive one dose of the non-therapeutic administration of a radioactive tracer called N-13 ammonia(13NH3) , then undergo one total body 13NH3 PET/CT Scan (uEXPLORER) to determine the blood flow value of the brain, kidney and other organs. The total body 13NH3 PET/CT Scan will allow investigators to observe and analyze the real-time blood flow differences between patients with between healthy controls and decreased cardiac function.
Interventions
DEVICEtotal-body PET/CT(uEXPLORER , United Imaging Healthcare, China)
This prospective study will enroll twenty-five patients, including nine healthy volunteers, sixteen patients with decreased cardiac function . All of them will have a whole-body PET/CT(uEXPLORER , United Imaging Healthcare, China) in our department, Renji Hospital.
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Nine healthy volunteers with normal EF values * Patients with decreased cardiac function, while their heart function grading above II(New York Heart Association,NYHA) * Aged 60\~90 years old * Written informed consents will be offered and signed by all participants
Exclusion criteria
* History of vascular-related diseases in other organs * Severe liver and kidney dysfunctions * Patients who are pregnant or breast feeding * People under the age of 60 years old * Heart function grading below II(NYHA) * inability to lie or to maintain posture in the scanner for one hour
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of Multi-Organ Blood Perfusion by Total Body Dynamic uEXPLORER PET/CT Scan | 4 years | The total-body 13N-NH3 PET/CT will be adopted to evaluate the blood flow differences in whole body between healthy controls and patients with decreased cardiac function. |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORYumei Chen, Ph.D; M.D.
RenJi Hospital
Outcome results
None listed