Nephrogenic Diabetes Insipidus
Conditions
Brief summary
The investigators aim to retrospectively explore the electronic medical records of all patients who were admitted to the Intensive Care Unit (ICU) of the UZ Brussels in the last 10 years (March 1st 2011- March 1st 2021) and who received prolonged sedation (\>24h) with sevoflurane.
Interventions
DRUGSevoflurane
Sevoflurane administration to sedate the patient
Sponsors
Universitair Ziekenhuis Brussel
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Sevoflurane administration \>24h * 18 years and older
Exclusion criteria
* \< 18 years old * Pre-existing diabetes insipidus * Use of drugs at risk for diabetes insipidus (including lithium, cisplatin) * Hypercalcemia (persistently \>2.75 mmol/L) * Pituitary or acute brain surgery * Patients requiring continuous renal replacement therapy * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nephrogenic Diabetes Insipidus prevalence | up to 8 weeks | How many patients under sevoflurane sedation ultimately develop NDI? NDI confirmed by demonstrating the absence of a urine concentrating response to exogenous Arginine Vasopressine. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of symptoms of NDI | up to 8 weeks | Number of symptoms of NDI do these patients show? |
| Number of patients with an abnormal physical examination. | during hospitalization, up to 8 weeks. | Typical physical symptoms of (N)DI: tired, lethargic, tachycardia, tachypnea, hypotension and dry mucous membranes. |
| Number of patients with urine with an abnormal osmolality | during hospitalization, up to 8 weeks. | Lab testing of urine: osmolality \< 300 mosm/kg |
| Number of patients with electrolyte abnormalities as assessed by lab results. | during hospitalization, up to 8 weeks. | Lab results of hematology and chemistry labs show an electrolyte imbalance. |
| Number of patients that have an abnormal abdominal echo of the bladder. | during hospitalization, up to 8 weeks. | Echo shows an enlarged bladder. |
| Amount of time patient was placed under sevoflurane sedation. | up to 8 weeks | How long are they under sevoflurane sedation. |
| Number of patients with excessive urine output | during hospitalization, up to 8 weeks. | Amount of urine output: \>40 ml/kg/24h |
| Number of patients that show an abnormal amount of fluid intake | during hospitalization, up to 8 weeks. | \>2.5l/day |
| Timing of symptoms of NDI | up to 8 weeks | After how much time do these patients show symptoms of NDI? |
| Number of patients that develop risk factors of NDI | up to 8 weeks | Number of patients that develop risk factors (electrolyte disorder, urinary obstruction) for NDI. |
Countries
Belgium
Outcome results
None listed