Methylation Effects of COV-19 Infection and Vaccinations

Measuring the DNA Methylation Effects From COVID-19 Infection and COVID-vaccinations

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04939155

Enrollment

Registered

2021-06-25

Start date

2021-03-10

Completion date

2022-03-10

Last updated

2021-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid19

Brief summary

This is a retrospective non-randomized clinical study of 60 patients total to assess the effects of SARS-CoV-2 infection and the SARS-CoV-2 vaccination. This study will have 2 arms evaluating the epigenomes of patients pre and post-exposure to one of the interventions. The first arm of the study will analyze 40 patients' epigenomes whose DNA methylation was examined pre and post SARS-CoV-2 infection. The second arm of this study is analyzing 20 patients' epigenomes whose DNA methylation was examined pre and post-injection of the SARS-CoV-2 vaccine.

Interventions

BIOLOGICALSARS-CoV-2 mRNA vaccine

mRNA vaccine for COVID

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Subjects that are healthy individuals and of any sex, ethnicity, and anyone above the age of 18 years old.

Design outcomes

Primary

Measure	Time frame	Description
Methylation age clock testing	Change from baseline after COVID-19 infection	The DNA clocks that will be used to precisely measure aging is TruAge Biological Age test, which estimates biological age vs. chronological age

Secondary

Measure	Time frame	Description
Overall state of health	Change from baseline after COVID-19 infection	Questionnaire assessing overall health

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026