Lung Cancer
Conditions
Keywords
Screening
Brief summary
Guangzhou Lung-Care Project is a single-arm, prospective cohort study using one-time low-dose computed tomography for the early detection of LC, recruiting residents aged 40-74 years from four communities in Guangzhou between 2015 and 2021.The primary outcome was LC detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases, and to investigate the various factors associated with the development of LC.
Detailed description
Guangzhou Lung-Care Project is a single-arm, prospective cohort study using one-time low-dose computed tomography for the early detection of LC, recruiting residents aged 40-74 years from four communities in Guangzhou between 2015 and 2021. Follow-up for post-screening management and survival was recorded. The primary outcome was LC detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases, and to investigate the various factors associated with the development of LC. Additionally, we compared the detection rates of LC and the proportion of stage I LC cases between high-risk and non-high-risk groups according to the National Comprehensive Cancer Network (NCCN) guidelines and Chinese guideline.
Interventions
The Low-dose computed tomography is conducted according to the guideline suggested by American College of Radiology.
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 74 Years
Healthy volunteers
Yes
Inclusion criteria
* Minimum age of 40 years among the residents in Guangzhou
Exclusion criteria
* Persons who had a diagnosis or treatment related to LC within the past 5 years, had undergone chest CT within the past year, or had significant cancer-related symptoms (e.g., hemoptysis, dyspnea, inability to climb two flights of stairs).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The detection rate of lung cancer | 11 years | Lung cancer detection rate in eligible participants without restrictions based on high-risk factors and the proportion of stage I LC cases. |
| To investigate the various factors associated with the development of lung cancer | 11 years | To investigate the various factors associated with the development of lung cancer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Detection rates of lung cancer and the proportion of stage I lung cancer cases between high-risk and non-high-risk groups | 11 years | The detection rate of lung cancer among people with high-risk and non-high-riskfactors |
| Cost-effectiveness ratio (costs of examinations, diagnoses, and treatments) | 11 years | — |
Countries
China
Contacts
Primary ContactWenhua Liang, MD
Outcome results
None listed