Subarachnoid Hemorrhage, Aneurysmal
Conditions
Keywords
subarachnoid hemorrhage, coagulation, inflammation
Brief summary
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
Detailed description
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage (SAH). 1.40 patients with SAH will be included. The CSF will used for ELISA test for inflammatory factors and cogulation factors. 2.CSF obtained from 4 patients with non-neuroloogical disease with 4 addittional SAH patients will be used for Mass Spectrometry
Interventions
DIAGNOSTIC_TESTLumbar puncture
Lumbar puncture to obtain the cerebrospinal fluid and for diagnostic test
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* SAH patients with modified Fisher Scale 3-4.
Exclusion criteria
* Patients with history of CNS disease (e.g., stroke, traumatic brain injury, CNS infection) or accompanied by serious comorbidities before SAH onset (e.g., severe coagulation disorders, malignant tumor, uncontrollable heart disease, and hypertension) or other organ dysfunctions within 6 months were excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | evaluated 1day after discharge | Length of hospital stay |
| modified Rankin Scale | evaluated 1day after discharge | modified Rankin Scale (mRS) at discharge. mRS ranging from 0-5, higher represents worse |
| Glasgow Outcome Scale | evaluated 1day after discharge | Glasgow Outcome Scale (GOS) at discharge, GOS ranging from 0-5, higher represents better |
Countries
China
Outcome results
None listed