Proximal Tubule Dysfunction, SARS-CoV2 Infection
Conditions
Brief summary
The primary goal is to detect Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV2) urine viral particles in patients in intensive care units, hospitalized for coronavirus Coronavirus Disease-19 (COVID-19) infection, and correlate the presence of the virus in the urine with proximal tubular dysfunction (defined by the association of at least 2 abnormalities: tubular proteinuria, renal phosphate leak, uricosuria, normoglycemic glycosuria, amino aciduria)
Interventions
OTHERRT-PCR SARS-COV2 in urine
proteinuria/renal phosphate leak/uricosuria/glycosuria/ aminoaciduria)
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Person and / or trustworthy person who has received complete information on the organization of the research and who has not opposed their participation and the use of their data * Hospitalized for ≥ 48 hours and ≤ 10 days * SARS-CoV-2 positive nasopharyngeal sample * Severity criteria: Lung involvement described as compatible with SARS-CoV-2 on radiography or scanner and partial pressure of oxygne (PaO2) / Fraction of inspired oxygen (FiO2) ≤ 300 mmHg and / or respiratory rate (RR) ≥ 30 / min
Exclusion criteria
* Known chronic kidney disease, or initial Glomerular Filtration Rate (GFR) \<60 ml / min / 1.73m2 or Renal Transplant * Known proteinuria * Known proximal tubulopathy * Treatment with Forxiga
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SARS-CoV 2 viruria and its correlation with proximal tubule dysfunction | During the first 10 days of hospitalization | Is the detection of viral particles in urine associated with proximal tubule dysfunction, defined by two or more of the following : proteinuria, phosphate leak, aminoaciduria, hyperuricuria, and/or glycosuria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Capacity of infection of urine viral particles | During the first 10 days of hospitalization | Study of the capacity for cell infection in vitro by viral particles detected in urine. |
| Sequencing viral particles to identify possible compartmentalization of the virus | During the first 10 days of hospitalization | Study by sequencing of the compartmentalization of urinary and nasopharyngeal variants of SARS-CoV-2 in patients with positive urine for SARS-CoV-2. |
Countries
France
Contacts
Primary ContactRaphaël Kormann
Outcome results
None listed