MDRO
Conditions
Brief summary
Survey on the prevalence of MDRO to monitor the import of MDRO from the community. Rectal swabs will be taken and cultivated. Survey on community-onset and nosocomial bloodstream infections will be documented and strains will be isolated. For each BSI a clinical data set will be obtained (e.g. patient age, gender, date of hospitalization, antibiotic therapy). Genetic analysis of MDRO from the prevalence and BSI study. In a subset of patients the microbiome-resistome interactome will be analysed in more detail. Furthermore, the impact of infection control measures due to the Covid-19 pandemic on nosocomial BSI will be investigated.
Interventions
OTHERrectal swab
collection of rectal swabs
Sponsors
University Hospital of Berlin
University Hospital of Cologne
University Hospital Freiburg
University of Giessen
University Hospital Tuebingen
University of Luebeck
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* at least 18 years old * informed consent * inpatient
Exclusion criteria
* less than 18 years old * Not capable of giving informed consent * outpatient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| monitoring of MDRO prevalence | at hospital admission | obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure |
| monitoring of blood stream infections | during hospitalization, up to 4 weeks | obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure |
| integrate novel techniques for microbiome-resistome interaction analysis | through study completion, after 4 years | obtain a better understanding for the emergence of resistance within the microenvironment under selective pressure |
Countries
Germany
Outcome results
None listed