Ventilation-perfusion (V/Q) Ratio and Alveolar Surface Area in Preterm Infants

Functional Morphometry and Ventilation Perfusion Ratio to Estimate the Alveolar Surface Area in Prematurely Born Infants

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04936477

Enrollment

Registered

2021-06-23

Start date

2020-09-29

Completion date

2023-01-30

Last updated

2023-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchopulmonary Dysplasia

Brief summary

To non-invasively estimate the alveolar surface area of the lungs of prematurely born infants by taking measurements of oxygen and carbon dioxide and utilizing functional morphometry.

Interventions

OTHERCalculation of ventilation-perfusion ratio

Three to five paired measurements of fraction of inspired oxygen and peripheral oxygen saturations. Insertion of mainstream capnograph with combined pressure and flow sensor to perform end-tidal capnography measurement. Echocardiogram to assess intra-cardiac shunting.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

22 Weeks to 28 Weeks

Healthy volunteers

Inclusion criteria

Exclusion criteria

* Congenital or chromosomal anomalies

Design outcomes

Primary

Measure	Time frame
Calculation of the alveolar surface area in prematurely born infants using validated functional morphometry	One year

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026