Gender Dysphoria, Adult
Conditions
Brief summary
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.
Detailed description
Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity. Gender dysphoria is accompanied by the often overwhelming need for a hormonal or even hormone-surgical transition. Gender dysphoria is very often characterized by fluctuating mood sadness, irritability, obsessionality. An improvement in the quality of life after medical treatment (hormone therapy) and gender reassignment surgery has been described in the literature. Morphological similarities have been found between the brains of women and the brains of so-called transgender women, as well as between the brains of transgender men and men. These morphological data are only very fragmentary and have not been supported by neuro-functional data. Self-awareness, which refers to the awareness that an individual has of his body, his image and his own identity, is partly underpinned, at the brain level, by the activation of the Default Mode Network (DMN) at rest, in non-pathological conditions. The conflict between the internal perception of the own body and its objective representation could result in a change in brain connectivity within the DMN, due in particular to changes in the activation of the temporo parietal junction.
Interventions
OTHERPsychiatric evaluations
At different time points, several psychiatric evaluations will be performed on patients and volunteers for study purposes
Sponsors
Centre Hospitalier Henri Laborit
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with gender dysphoria * Without psychotropic * Without hormono-therapy * Without sexual surgery assignation
Exclusion criteria
* Any depression * Any addiction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Contribution of temporal parameters of microstates C, D, E and F | Week 1 to Week 24 | The proportion of the total time spent in microstates of class C,D,E and F |
| Duration of temporal parameters of microstates C, D, E and F | Week 1 to Week 24 | — |
| Mean-Global Field Power temporal parameters of microstates C, D, E and F | Week 1 to Week 24 | — |
| Occurrence of temporal parameters of microstates C, D, E and F | Week 1 to Week 24 | — |
| Cortical voxel activity from source reconstruction analysis, using electroencephalogram during Double Mirror Test (D.M.T). | Week 1 to Week 24 | — |
Countries
France
Contacts
Primary ContactBérangère Thirioux, PhD
Outcome results
None listed