Asthma
Conditions
Keywords
Asthma, Resistance Training, Endurance Training, Quality of Life
Brief summary
Emerging evidence suggests that regular exercise can complement medical treatment for asthma. Furthermore there are no specific recommendation on how plan exercise training. To the best of current knowledge, there isn't enough evidence of the effect of a strength training in subjects with asthma. Therefore the aim of this study is to evaluate the short and long term effects of a strength and endurance training compared with endurance training alone in subjects with asthma.
Detailed description
To the best of current knowledge, there isn't enough evidence of the effect of a strength training in subjects with asthma. Aim of the study is evaluate the short (after pulmonary rehabilitation) and long term (after 12 months) effects of a strength and endurance training compared with endurance training alone in improving quality of life and disease control in subjects with asthma of Global Initiative for Asthma (GINA) stage from 4 to 5.This is a prospective randomized control trial. Subjects with diagnosis of asthma according to the GINA guidelines admitted to a reference centre for inpatient pulmonary rehabilitation will be randomly assigned to study or control group.
Interventions
PROCEDUREStandard Program + Endurance and Strength training
Sessions of strength training added to a standard inpatient multidisciplinary programme
PROCEDUREStandard Program
Standard inpatient multidisciplinary programme (including endurance training)
Sponsors
Istituti Clinici Scientifici Maugeri SpA
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of asthma step 4 to 5 under optimal medical treatment for at least 6 months according to GINA guideline * Symptomatic despite being on treatment: Asthma Control Test (ACT) score ≥ 20 ≤24 * Able to perform and complete with studies procedures (FeNO, CPET, Six Minute Walking Test (6MWT), MVS.
Exclusion criteria
* Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) according to the Global initiative for Obstructive Lung Disease (GOLD) guidelines criteria * Smokers or ex-smokers with pack/years ≥10 * Body Mass Index (BMI) ≥30 * Change in asthma medications in the last 30 days * Cognitive impairment (Mini-Mental State Examination score \<22) * History of oncological, neurological, cardiovascular diseases, musculoskeletal impairment and/or medical diseases precluding exercise testing and pulmonary rehabilitation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| asthma related Quality of Life | 4 weeks from enrollment | Asthma Quality of Life Questionnaire (AQLQ). Range 0 (worst) - 7 (best) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Eosinophilic airway inflammation | 4 weeks from enrollment | Fractional Exhaled Nitric Oxide (FeNO), |
| Aerobic capacity | 4 weeks from enrollment | Maximum oxygen capacity (VO2max) assessed by Cardio Pulmonary Exercise Test, (CPET). |
| Asthma control | 4 weeks from enrollment | Asthma Control Questionnaire (ACQ-6). Range 0 (best) - 6 (worst) |
| Treatment satisfaction | 1 year | Global Perceived Effect (GPE) score 1 (best) - 7 (worst) |
| Numbers of exacerbations | 1 year | number of exacerbations in the last 12 months. |
| Quadriceps and biceps strength | 4 weeks from enrollment | Maximal Voluntary isometric Strength (MVS). |
Countries
Italy
Outcome results
None listed