Blood Pressure, Low
Conditions
Keywords
Blood Pressure, Catecholamines, Heart failure, High risk patients, Left ventricular assist device
Brief summary
The induction of anesthesia is one of the most critical situations for high-risk-patients undergoing major surgery. For several reasons, it is crucial to maintain adequate blood pressure and cardiac output during this phase. This observational study aims to find out if the choice of the induction agent has a major impact on blood pressure and the use of antihypotensive drugs during the induction and the surgical procedure in heart-failure patients undergoing the implantation of a left ventricular assist device (LVAD).
Interventions
DRUGEtomidate
Use of etomidate during induction as decided by attending anesthesiologist
DRUGMidazolam
Use of midazolam during induction as decided by attending anesthesiologist
DRUGSevoflurane
Use of sevoflurane during induction as decided by attending anesthesiologist
Sponsors
Heidelberg University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Heart failure patients scheduled for implantation of left ventricular assist device (LVAD)
Exclusion criteria
* Pregnancy * Presence of another cardiac assist device in the patient (for example ECLS) * No consent of the patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-Induction hypotension | First 30 minutes after induction of anesthesia | The incidence of hypotension in the first 30 minutes after the induction of anesthesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Antihypotensive drugs during the procedure | Begin of the procedure until end of the procedure | Use of antihypotensive drugs during the procedure |
| Length of stay on the intensive care unit (ICU) | After the procedure and transport to intensive care unit, total time in hours until submission from I. Expected time frame is 48 to 96 hours.CU | The time the patient has to be treated on intensive care unit after the procedure (in hours) before submission. |
| Antihypotensive drugs after induction | First 30 minutes after induction of anesthesia | Use of antihypotensive drugs during the first 30 minutes after induction of anesthesia |
| Kidney | First 28 days after procedure | Occurrence of acute kidney failure as defined by Kidney Disease: Improving Global Outcomes (KDIGO) |
| Mortality | First 28 days after procedure | Mortalitiy in the first 28 days after the procedure |
| Delirium | First 24 hours after the end of the procedure | Diagnosis of postoperative delirium |
Contacts
Primary ContactAdrian E Stephan, MD
Outcome results
None listed