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The Effect of Joint Hypermobility Syndrome on Delayed Onset of Muscle Soreness and Recovery Time

The Effect of Joint Hypermobility Syndrome on Delayed Onset of Muscle Soreness and Recovery Time

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04934267
Enrollment
20
Registered
2021-06-22
Start date
2021-05-01
Completion date
2022-05-15
Last updated
2021-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypermobility Syndrome

Keywords

DOMS, Hypermobility,, Recovery

Brief summary

The purpose of the study is to investigate Joint Hypermobility Syndrome (JHS) and its effect on delayed onset muscle soreness (DOMS) and recovery time. The hypothesis is that people with JHS will experience increased DOMS when compared to non-hypermobile people. The results this study may assist and add to the body of knowledge when treating and exercising patients with JHS, as considerations can possibly be made when treating this population. Subjects with JHS may experience greater DOMS and require more time to recover between treatment sessions.

Detailed description

The research design will be a 2x5 factorial design. There will be two groups, an experimental group with hypermobile individuals, and a control group with individuals that are not hypermobile with normal ranges of motion. All participants will take part in an exercise session with eccentric bicep curls based on their 1 repetition maximum (1-RM), which is the highest amount of weight that they can lift concentrically once. The independent variables are the two groups and the dependent variables are girth, resting arm angle (RANG), Pain 1-10 Visual Analogue Scale (VAS), McGill Pain Questionnaire, and pressure pain threshold using an algometer. The proposed study will include 20 participants between the ages of 18-35 years old, who exercise recreationally. Both groups will perform 1 set of standing eccentric bicep curls based on their 1RM to failure in order to induce DOMS.7 Each rep will include a timed 5 second long eccentric component with a metronome and without an concentric component, as the research conductors will lift the weight up or concentrically for the participant. The exercise will stop when the participant cannot volitionally keep up with the 5 second count lowering the weight. Prior to exercise, baseline measurements will be taken for all dependent variables. These measures will be taken every day at the same time of day,for the next 4 days. Girth is the measurement of the circumference of a limb measuring swelling, which commonly occurs during DOMS.7 Resting Arm Angle (RANG) is a range of motion (ROM) measurement of the arm while resting.The VAS is a simple pain scale ranging from 0-10, 0 being no pain and 10 being the worst pain the participant has felt..The McGill Pain Questionnaire is a questionnaire that allows the participant to rate their pain'.7 Lastly, the pressure pain threshold using an algometer is done by applying continuous ascending pressure at a constant rate in order to quantify the individuals pain pressure threshold.The change in measurements from baseline to post exercise will be recorded for subsequent data analysis.

Interventions

OTHEREccentric Exercise for subjects with JHS

There will be two groups, an experimental group with hypermobile individuals, and a control group with individuals that are not hypermobile with normal ranges of motion. All participants will take part in an exercise session with eccentric bicep curls based on their 1 repetition maximum (1-RM), which is the highest amount of weight that they can lift concentrically once. The independent variables are the two groups and the dependent variables are girth, resting arm angle, Pain, McGill Pain Questionnaire, and pressure pain threshold. This groups will perform 1 set of standing eccentric bicep curls order to induce DOMS.Each rep will include a timed 5 second long eccentric component without an concentric component,. The exercise will stop when the participant cannot volitionally keep up with the 5 second count. Prior to exercise, baseline measurements will be taken for all dependent variables. These measures will be taken every day at the same time of day,for the next 4 days.

OTHEREccentric Exercise for Controls

There will be two groups, an experimental group with hypermobile individuals, and a control group with individuals that are not hypermobile with normal ranges of motion. All participants will take part in an exercise session with eccentric bicep curls based on their 1 repetition maximum (1-RM), which is the highest amount of weight that they can lift concentrically once. The independent variables are the two groups and the dependent variables are girth, resting arm angle, Pain, McGill Pain Questionnaire, and pressure pain threshold. This groups will perform 1 set of standing eccentric bicep curls order to induce DOMS.Each rep will include a timed 5 second long eccentric component without an concentric component,. The exercise will stop when the participant cannot volitionally keep up with the 5 second count. Prior to exercise, baseline measurements will be taken for all dependent variables. These measures will be taken every day at the same time of day,for the next 4 days.

Sponsors

New York Institute of Technology
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE

Intervention model description

Comparing the recovery times and length of DOMS in individuals with JHS to individuals with normal ranges of motion in response to exercise

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

1. Age range: 18-35 years 2. Good overall health 3. Regularly participate in recreational exercise 4. 10 subjects with normal ranges of motion (score of \<4 on Beighton Scale), 10 subjects with increased ranges of motion (score of \>4 on Beighton Scale AND hypermobile in the elbow)

Exclusion criteria

1. Individuals with Ehler-Danlos Syndrome. 2. Any major musculoskeletal injuries in the last 6 months. 3. Any recent traumas that could lead to acute hypermobility or instabilities 4. Any known disorders that impede recovery/healing time (i.e. Lupus, Rheumatoid Arthritis, Scleroderma). 5. Any other health issues that would risk the safety of the subject.

Design outcomes

Primary

MeasureTime frameDescription
Change is being assessed in Girth between the 5 time pointsBaseline (Day 1) through Day 2,3,4 and 5.Girth is the measurement of the circumference of a limb in centimetres, measuring edema, which commonly occurs during DOMS.
Change' is being assessed in Resting arm angle (RANG)between the 5 time points,Baseline (Day 1) through Day 2,3,4 and 5.Resting Arm Angle (RANG) is a Range Of Motion measurement in degrees of the arm while resting
Change is being assessed in Visual Analogue Scale (VAS) of Pain between the 5 time pointsBaseline (Day 1) through Day 2,3,4 and 5.The VAS is a simple pain scale ranging from 0-100 mm, 0 being no pain and 100 mm being the worst pain the participant has felt.
Change is being assessed in The McGill Pain Questionnaire (SF-MQ2)between the 5 time pointsBaseline (Day 1) through Day 2,3,4 and 5.The McGill Pain Questionnaire (SF-MQ2) is a questionnaire that allows the participant to rate their pain.
Change is being assessed in Algometer pain pressure threshold between the 5 time pointsBaseline (Day 1) through Day 2,3,4 and 5.the pressure pain threshold using an algometer is done by applying continuous ascending pressure at a constant rate on their self reported most painful area surrounding the elbow in order to quantify the individuals pain pressure threshold, measured in kg.

Countries

United States

Contacts

Primary ContactPeter C Douris, EdD
pdouris@nyit.edu5162486332

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026