Overweight and Obesity
Conditions
Brief summary
This prospective study intends to explore the change of cardiac structure and function in the cohort of overweight or obesity patients, and determine the impact of clinical characteristics on cardiac remodeling and mechanics.
Detailed description
Obesity significantly increases the risk for heart failure. Early detection of preclinical cardiac dysfunction in overweight or obesity and understanding its association with insulin resistance are of great importance.Recently, a novel technique for myocardial work (MW) assessment has been introduced to evaluate myocardial performance. To date, change of MW has been described in several cardiac conditions including dilated cardiomyopathy, significant coronary arterial diseases, and hypertrophic cardiomyopathy, which implies regional or global myocardial dysfunction. In this study, we aimed to explore the alteration of MW in overweight or obese adults and to determine whether insulin resistance or other clinical risk factors may impact myocardial mechanics before impairment of systolic function.
Interventions
DIAGNOSTIC_TESTMyocardial work was estimated from left ventricular pressure-strain loop derived from speckle tracking echocardiography and non-invasive brachial artery cuff pressure
Baseline and follow-up examination of echocardiography is to be performed on study subjects.
Sponsors
Ningbo Hangzhou Bay Hospital
Jiading Central Hospital
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* All patients were older than 18 without any cardiac symptoms. * The diagnosis of overweight was established when body mass index (BMI) of 25 to 30 kg/m2. * Obese was defined as a BMI of 30 kg/m2 or higher.
Exclusion criteria
* diagnosis of type 2-Diabetes Mellitus according to the American Diabetes Association criteria; * left ventricular ejection fraction\<50% on echocardiography; * arrythmia on electrocardiogram; * severe valvular stenosis or regurgitation; * history of coronary disease (defined as stenosis\>50%) or myocardial infarction; * stress induced wall motion abnormality on echocardiography, coronary artery stenosis \>50% on coronary CT or angiography with Framingham risk score of \>10; * pacemaker or defibrillator implantation; * the presence of bundle branch block; * severe infection or renal dysfunction with an estimated glomerular filtration rate \< 60 ml/min/1.73 m2); * inadequate image quality on echocardiography.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| investigate the change of global myocardial work index (GWI) in overweight or obese patients | within 24 hours of the recruitment | GWI derived from echocardiography will be assessed in overweight or obese patients and compare with lean controls |
| investigate the change of global constructive work (GCW) in overweight or obese patients | within 24 hours of the recruitment | GCW will be assessed in overweight or obese patients and compare with lean controls |
| investigate the change of global waste work (GWW) in overweight or obese patients | within 24 hours of the recruitment | GWW will be assessed in overweight or obese patients and compare with lean controls |
| investigate the change of global work efficiency (GWE) in overweight or obese patients | within 24 hours of the recruitment | GWE will be assessed in overweight or obese patients and compare with lean controls |
Countries
China
Contacts
Primary ContactHang Zhao
Outcome results
None listed