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Musculoskeletal Symptoms in Post Acute Covid-19 Patients

Musculoskeletal Symptoms and Related Factors in Post Acute Covid-19 Patients

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04932889
Enrollment
280
Registered
2021-06-21
Start date
2021-06-11
Completion date
2021-06-14
Last updated
2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid19, Musculoskeletal Abnormalities

Brief summary

The patients whose musculoskeletal symptoms initiated or aggravated with Covid-19, were compared with the patients whose musculoskeletal symptoms did not change with Covid-19. The variables; the demographic and treatment datas, admission symptoms, post acute-Covid-19 symptoms, laboratory, chest computed tomography findings.

Detailed description

There is a lack of an overview of the factors associated with post acute-Covid-19 musculoskeletal symptoms. The aims are;1-to evaluate the most frequent admission symptoms and the frequency of musculoskeletal symptoms in post acute-Covid-19 patients,2-to determine the related factors with the post acute-Covid-19 musculoskeletal symptoms. In this retrospective study; the patients whose musculoskeletal symptoms initiated or aggravated with Covid-19, were compared wthe patients whose musculoskeletal symptoms did not change with Covid-19. The variables; the demographic and treatment datas, admission symptoms, post acute-Covid-19 symptoms, laboratory (complete blood count, C-reactive protein, ferritin, D-dimer), chest computed tomography findings.

Interventions

OTHERSurvey

A detailed anamnesis was retrospectively recorded about age, gender, body mass index, education, working, the presence of any chronic disease (diabetes mellitus, hypertension, chronic obstructive pulmonary disease, cardiac disease, cancer, rheumatological disease…), smoking, duration of symptoms, usage of supplementing vitamins such as vitamin D,C, zinc…, treatment place (home quarantine, hospital, intensive care unit), duration of home quarantine and hospital treatment, the number of months since the onset of Covid-19 symptoms, usage of anticoagulants, treatment drugs such as hydroxychloroquine, favipiravir. Also the symptoms during the period of Covid-19 infection were recorded from patient files; cough, fever, dyspnea, chest pain, loss of smell and taste, sore throat, headache, no symptom, musculoskeletal symptoms such as: muscle, low back, back, joint pain.

OTHERLaboratory parameters

The laboratory values of 182 patients, presence of chest computed tomography findings of 206 patients and symptoms of all patients during the period of Covid-19 infection, were retrospectively recorded. Laboratory values of hemoglobin, leucocyte, lymphocyte, platelet, C-reactive protein, erythrocyte sedimentation rate, ferritin, d-dimer, were recorded.

Typical findings of chest CT were; bilateral, multifocal, peripheral ground glass opacities with/without consolidation, including the fissures, close to visceral pleural surfaces. Covid-19 Reporting and Data System (CO-RADS) was used for chest CT. CO-RADS assigns scores from 1 (very low suspicion of Covid-19) to 5 (very high suspicion of Covid-19).

Sponsors

Eskisehir City Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Being 18 years or older * Having Covid-19 treatment (home quarantine / hospital / intensive care unit) according to a positive polymerase chain reaction (PCR) test in a nasopharyngeal + oropharyngeal swab or chest CT.

Exclusion criteria

* Patients who did not have musculoskeletal symptom records (admission symptoms and musculoskeletal symptoms such as; fatigue, spine / joint /muscle pain/ numbness) in patients files * Acute Covid-19 patients whose symptoms started less than 1 month

Design outcomes

Primary

MeasureTime frameDescription
Rate of back painBaselinegiven as percentage %
Chest computed tomographyBaselinePresence of covid-19 findings in chest computed tomography (covid findings positive or negative)
Rate of low-back painBaselinegiven as percentage %
Rate of fatigueBaselinegiven as percentage %
Rate of neck painBaselinegiven as percentage %
Rate of dyspneabaselinegiven as percentage %
Rate of joint painBaselinegiven as percentage %
Rate of chest painBaselinegiven as percentage %
Rate of myalgiaBaselinegiven as percentage %

Secondary

MeasureTime frameDescription
ageBaselineyears
FerritinBaselinenanogram/mililitre
WeightBaselinekilograms
genderBaselinefemale or male
Duration after the onset of covid-19Baselinemonths
Lymhocyte levelsBaseline10\*3 cells/microliter
D-dimer levelsBaselinemiligram/Litre
C-reactive proteinBaselinemiligram/Litre
HemoglobinBaselinegram/desilitre
PlateletBaseline10\*3 cells/microliter

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026