NSCLC Stage IIIB, NSCLC Stage IV
Conditions
Brief summary
This study aims to understand the metastasis in advanced NSCLC through comparing genomic and transcriptomic patterns between the circulating tumor cells and metastatic tumor cells by single cell sequencing analysis.
Interventions
DIAGNOSTIC_TESTcohort study
no intervention
Sponsors
CytoGen, Inc.
UNIST (Ulsan National Institute of Science and Technology)
Samsung Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* All subjects need to sign the informed consent form * All subjects have non-small cell lung cancer which suspected on chest CT or confirmed pathologically preoperatively * Treatment naïve advanced lung cancer (including extensive stage IIIb and stage IV) * Patients who were suitable to provide enough metastatic tumor tissue and blood (30ml) for the single cells sequencing
Exclusion criteria
* Patients with previous history of lung cancer * Have been undergone chemotherapy or radiotherapy due to non-small call lung cancer * Have been diagnosed any type of cancer other than cancer of skin, thyroid, uterine cervix within 5 years before enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The gene expression and the cell population | 3 year | Methods for the single cell RNA sequencing and whole exome sequencing of the tumor cells With the tissue biopsied specimens, scRNAseq (by 10X Genomics platform) and whole exome seq will be carried out. |
Countries
South Korea
Outcome results
None listed