Risk Factors of ICU-acquired Weakness

ICU-acquired Weakness in Extracorporeal Membrane Oxygenation Support: Frequency and Risk Factors

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04932330

Acronym

ICU-AW

Enrollment

Registered

2021-06-21

Start date

2017-03-01

Completion date

2022-06-01

Last updated

2021-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU Acquired Weakness

Keywords

ICU Acquired Weakness, Extracorporeal Membrane Oxygenation

Brief summary

We conducted a retrospective study of critical ill patients who used ECMO during their ICU stay. ICU-AW was diagnosed at the time when patients discharged and had a Medical Research Council (MRC) sum score \< 48 out of a maximal score of 60. We divided patients to ICU-acquired weakness group and no ICU-acquired weakness group and compared their clinical characteristics. Baseline characteristics and therapy details were collected from the case report forms and inspection reports. Univariable analysis and logistic regression analysis were used to analyze clinical characteristics of individuals and to find risk factors of ICU-AW.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Critical ill patients who used extracorporeal membrane oxygenation during their ICU stay. Patients were recruited from the general ICU of the second affiliated hospital of Zhejiang University, between March 2017 to March 2020.

Exclusion criteria

* Patients who was less than 18 years old, had been proven or suspected neurological impairment, using extracorporeal membrane oxygenation less than 24 hours, severe head or spinal cord injury and pregnant woman.

Design outcomes

Primary

Measure	Time frame	Description
Differences between ICU-acquired weakness in patients receiving extracorporeal membrane oxygenation support	1 day	We compared the clinical characteristics between ICU-acquired weakness group and no ICU-acquired weakness group by univariate analysis . Then we used logistic regression analysis and found out differences of ICU-acquired weakness.

Secondary

Measure	Time frame	Description
Frequency of ICU-acquired weakness in in patients receiving extracorporeal membrane oxygenation support	1 day	We calculated the prevalence of ICU-acquired weakness on the patients included in our research.

Countries

China

Contacts

Primary Contactxinyi chen, master

chenxinyi0323@zju.edu.cn19858875700

Backup Contactman huang, phD

Outcome results