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Comparision of IPACK and Periarticular Block With Adductor Block Alone After Total Knee Artroplasty

Comparision of IPACK and Periarticular Block With Adductor Block Alone After Total Knee Artroplasty: a Prospective Randomized Trial on Pain and Knee Function After Total Knee Artroplasty

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04931966
Enrollment
105
Registered
2021-06-18
Start date
2021-06-22
Completion date
2021-08-17
Last updated
2021-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteo Arthritis Knee

Keywords

Total knee arthroplasty, Peri articular infiltration, Ipack block, Adductor canal block

Brief summary

105 patients ASA I-III, undergoing total knee arthroplasty under spinal anesthesia, will be randomly assigned into one of three groups, namely group A (n=35), where an adductor canal block, group B (N:35) where an adductor canal block with IPCAK, and group C (n=35) where an adductor canal block with PAI will be performed preoperatively. All patients will receive a standardized multimodal approach. NRS scores will be evaluated in static and dynamic conditions during the first 48 hours postoperatively.

Detailed description

Total knee replacement (TKP) is accepted as one of the major orthopedic surgery that most patients suffer from pain in the postoperative period. The primary aim of this research is to compare the analgesic efficacy of infiltration between the popliteal artery and capsule of the knee(IPACK) with the periarticular block when an additional adductor canal block is used. In the literature, adductor canal block(ACB) and sciatic nerve block are used as part of multimodal analgesia for postoperative pain management of patients undergoing TKP. Nevertheless, ACB is found less effective for pain originating from the posterior part of the knee. Sciatic nerve block and periarticular injection(PAI) are commonly used blocks to improve the analgesic effect of ACB. Besides this, ACB is effective for pain originated from the posterior part of the knee. IPACK block is performed under ultrasound guidance and targets the articular branches of tibial, common peroneal, and obturator nerves with sparing lower extremity motor function. Patients scheduled for knee surgery under spinal anesthesia are included fort his study. All groups will be applied 0.03 mg/kg midazolam iv, then spinal anesthesia will be applied to 15 mg 0.5 % heavy bupivacaine. Three groups of 105 patients will be included in the study. Adductor Canal Block (ACB) (Group A ) (n:35): After the patients are given the supine position, under the guidance of the ultrasound linear probe, 10-15cm proximal to the knee joint, under the sartorius muscle, next to the femoral artery. After the saphenous is observed, 0.25% 20 mL of bupivacaine will be given Adductor + İPACK Grup ( group B) (n: 35): Adductor canal 0.25% 20 mL of bupivacaine will be administered. After the knee is flexed, after the convex probe is placed in the popliteal space, 20 ml of 0.25% bupivacaine will be injected into the area between the popliteal artery and the femur called IPACK Adductor + PAI ( group C) (n: 35): Adductor canal 0.25% 20 mL of bupivacaine will be administered. Patients will receive 60 ml of local anesthetic cocktail intraoperatively by the surgeon. At the end of the operation to the peri-articular area (posterior capsule, collateral ligament, quadriceps muscle). Cocktail consists of 40 ml 0.25% bupivacaine + 8 ml 8 mg morphine+12 ml saline. Routine multimodal analgesia will be used for postoperative analgesia

Interventions

PROCEDUREblock

Adductor canal block

PROCEDUREadductor canal block

adductor canal block bupivacain

Adductor Canal Block plus IPACK Block using bupivacaine

PROCEDUREadductor Canal Block plus PAI Block

Adductor Canal Block plus PAI Block using bupivacaine

Sponsors

Karaman Training and Research Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes

Inclusion criteria

* Physical status according to American Society of Anesthesiologists (ASA) I-III * Patients scheduled for total knee arthroplasty

Exclusion criteria

* Previous operation on same knee * Hepatic or renal insufficiency * Younger than 18 years old and older than 85 * Patients undergoing general anesthesia * Allergy or intolerance to one of the study medications * BMI \> 40 * ASA IV * Chronic gabapentin/pregabalin use (regular use for longer than 3 months) * Chronic opioid use (taking opioids for longer than 3 months, or daily oral morphine equivalent of \>5mg/day for one month)

Design outcomes

Primary

MeasureTime frameDescription
NRS scores48 hoursNumerical Rating Scale (NRS) scores (Range 0-10, 0=no pain, 10=the worse pain ever)

Secondary

MeasureTime frameDescription
Range of knee motion48 hoursDegrees of flexion
Complications48 hoursComplications
Patient satisfaction48 hoursPatients asked whether they would choose the same anaesthetic management in a future operation: Yes/No
Opioid consumption4-6-8-12-24 and 48 hoursAnalgesic consumption at 4-6-8-12-24 and 48 hours
Rate of postoperative nausea and vomitingPost-op 24 to 48 hoursnausea, vomiting
Patient mobilization2 daysPatient reporting time of first standing to the side of the bed and time up and go test 2 days
Incidence of adverse events related to nerve block proceduresPost-op 24 to 72 hoursmuscle weakness, systemic toxicity

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026