Acute Kidney Injury
Conditions
Keywords
Acute kidney injury
Brief summary
In recent years there has been a significant increase in the number of participants in high intensity and duration sports events. This type of physical exercise has been reported to lead to an apparently transitory deterioration in kidney function. The injury mechanisms involved in this process have not been fully studied, but several have been proposed as potential causes, such as tissue ischemia, disruption of the permeability of the glomerular basement membrane, damage to the ultra-structure of skeletal muscle, structural involvement of the renal parenchyma, exercise-associated hyperthermia or insufficient hydration during exercise. Urinary biomarkers, which are a more precise tool than serum creatinine when it comes to detecting subclinical kidney damage, may be key to elucidate the characteristics of exercise-related kidney injury. The aim of this study is to carry out an integrative analysis of the development of exercise-associated subclinical acute kidney injury.
Interventions
OTHER10 km continuous running
Trial participants will perform a 10 km continuous running exercise
OTHER1.5 km continuous swimming
Trial participants will perform a 1.5 km continuous swimming exercise.
Sponsors
Hospital Clínico Universitario de Valladolid
Gerencia Regional de Salud de Castilla y Leon
Instituto de Investigación Biomédica de Salamanca
Centro Regional de Medicina Deportiva de Castilla y León
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Trial participants will participate sequentially in two tests that involve high intensity physical exercise (10 km continuous running and 1.5 km continuous swimming). Both tests will be separated from each other a minimum of 30 days.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age ≥18 years. * Able to understand the objectives of the study and to provide informed consent. * Body mass index between 18.5 and 29.9 kg / m2 * Active sportsman/woman (defined as previous experience with the planned tests and performing vigorous-intensity aerobic activity at least three times per week).
Exclusion criteria
* History of chronic kidney disease, hypertension, uncontrolled diabetes (defined as fasting glucose levels ≥200 mg/dl or HbA1c ≥9%), peripheral vascular disease, heart disease, neurological disease or thyroid disease. * Use of NSAIDs in the 72h prior to the test. * Consumption of statins or anabolic steroids. * Some kind of major physical injury in the four months prior to the tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute change in urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels | 24 hours |
| Absolute change in urinary Kidney Injury Molecule-1 (KIM-1) levels | 24 hours |
Secondary
| Measure | Time frame |
|---|---|
| Absolute change in serum creatinine levels | 24 hours |
| Absolute change in proteinuria | 24 hours |
Countries
Spain
Outcome results
None listed