Stuttering, Stuttering, Adult, Stuttering, Childhood
Conditions
Keywords
Healthy children, Healthy Adults
Brief summary
This research is being done to better understand stuttering, specifically how people who stutter may process and/or produce speech. Eligible participants enrolled will complete a variety of computer and speech-based tasks on up to 2 visits.
Detailed description
The study team will update the record to include the secondary identification number once the NIH has released the funds.
Interventions
BEHAVIORALSpeech and non-speech tasks
Participants will complete speech tasks such as listening to and/or producing speech and non-speech sounds.
Sponsors
University of Michigan
National Institute on Deafness and Other Communication Disorders (NIDCD)
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
(adults who do not stutter): * 18-65 years old * English as primary language * Normal speech, language, hearing, cognition
Exclusion criteria
(adults who do not stutter) * Personal or family history of stuttering * Major medical or psychiatric illness Inclusion criteria: (adults who stutter) * Aged 18-65 years * English as primary language * Normal speech, language, hearing, cognition (other than stuttering) * Currently stutters
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Phase Locking Value (PLV) - Session 1 Speech Tasks | Session 1 (up to 4 hours) | Participants will hear a series of single syllables spoken rhythmically and will be instructed to whisper the syllable "tah" repeatedly while the recording is playing. The degree of synchronization (how well the participant's whispered syllables match the cadence of the recorded syllables they are listening to) will be measured by computing the PLV between subject's produced speech and the heard speech. The PLV is a vector with a value between 0 and 1 that reflects the phase difference between two signals, where 0 is a complete mis-match and a 1 is a perfect match. Adults were not instructed to attempt to match the cadence (Implicit task). Child participants were instructed to attempt to match the cadence (Explicit task). |
| Phase Locking Value (PLV) - Session 2 Speech Tasks | Session 2 (up to 4 hours) | Adult participants will hear a series of single syllables spoken rhythmically and will be instructed to whisper the syllable "tah" repeatedly while the recording is playing. Child participants did not attend Session 2. The degree of synchronization (how well the participant's whispered syllables match the cadence of the recorded syllables they are listening to) will be measured by computing the PLV between subject's produced speech and the heard speech. The PLV is a vector with a value between 0 and 1 that reflects the phase difference between two signals, where 0 is a complete mis-match and a 1 is a perfect match. Adults completed this task twice. For the first test, they were not instructed to attempt to match the cadence (Implicit task). For the second test, they were instructed to attempt to match the cadence (Explicit task). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| R Statistic (Resultant Vector Length) | Session 1 (up to 4 hours) | In tapping synchronization (sensorimotor synchronization) research, the R statistic generally refers to the resultant vector length derived from circular statistics, used to quantify the consistency and stability of a participant's tapping relative to a rhythmic stimulus. It ranges from 0 to 1. 0=Complete inconsistency (taps are uniformly distributed). 1=Perfect consistency (all taps occur at the exact same relative phase). |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATOREmily Garnett, PhD
University of Michigan
Participant flow
Pre-assignment details
145 participants were enrolled (signed consent form). 26 participants were either lost to follow up (n=15; including 2 participants between Visit 1 and Visit 2) or determined to be ineligible following enrollment (n=11).
Baseline characteristics
| Characteristic | — |
|---|---|
| Age, Continuous | 30.7 Years STANDARD_DEVIATION 10.3 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 2 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 53 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 1 Participants |
| Race (NIH/OMB) Asian | 9 Participants |
| Race (NIH/OMB) Black or African American | 15 Participants |
| Race (NIH/OMB) More than one race | 2 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 32 Participants |
| Region of Enrollment United States | 10 participants |
| Sex/Gender, Customized Female | 27 Participants |
| Sex/Gender, Customized Male | 39 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk |
|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 55 | 0 / 67 | 0 / 13 | 0 / 10 |
| other Total, other adverse events | 0 / 55 | 0 / 67 | 0 / 13 | 0 / 10 |
| serious Total, serious adverse events | 0 / 55 | 0 / 67 | 0 / 13 | 0 / 10 |
Outcome results
None listed