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Myofascial Pain and Central Sensitization

The Impact of Nociplastic Pain Features on the Response to Physical Therapy in Patients With Primary Myofascial Pain: A Pilot Study.

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04929171
Enrollment
30
Registered
2021-06-18
Start date
2016-05-02
Completion date
2019-11-23
Last updated
2025-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myofascial Pain, Physical Therapy

Brief summary

This prospective, observational cohort pilot study compared pain phenotyping and functional measures in 30 participants with non-acute neck and/or shoulder girdle pain consistent with primary myofascial pain at 3-months following a physical therapy referral to study the impact of their baseline degree of pain amplification.

Interventions

OTHERPhysical Therapy

Physical therapy for chronic upper quarter myofascial pain syndrome, as prescribed by the patients' physicians

Sponsors

University of Michigan
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* English-speaking participants * Diagnosed by their physician with non-acute (more than two weeks) neck and/or shoulder girdle primary myofascial pain * Referred to a physical therapy treatment.

Exclusion criteria

* In an effort to reduce the potential that another medical condition could lead to a secondary myofascial pain response, extensive comorbid exclusion criterion. * Use of chronic high-dose opioid medication greater than 100 mg oral morphine equivalents per day. * Individuals receiving or applying for compensation or disability. * The inability to provide informed consent. * Severe physical impairment (e.g., blindness, deafness) * Co-morbid medical condition limiting function (e.g., malignant cancer) * Reported illicit drug use * Severe psychiatric condition that would limit judgment. * Lack of internet access.

Design outcomes

Primary

MeasureTime frameDescription
Change in Neck Disability IndexBaseline to 3 monthsFunction neck scale with a total possible score of 50 indicating worse function compared to a score of 0.

Secondary

MeasureTime frameDescription
Change in PEG ScoreBaseline to 3 monthsMultidimensional measure for initial assessment and follow-up of chronic pain in a primary care setting. The average of 3 domains with an averaged score of 0 to 10; 0 means lower pain interference and 10 means higher pain interference with life.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026