Child and Maternal Health
Conditions
Brief summary
In this study, a multidisciplinary team of researchers was established including credible researchers from the UAE, Australia and the United Kingdom to launch the First United Arab Emirates 3-year birth cohort study. The study aims to recruit 250 pregnant Emirati women within their first trimester, which is defined by the study as from 8 to 12 weeks pregnant, recruited from obstetric and gynaecology clinics in the UAE. Participants will be recruited via face to face interviews and will receive a total of 11 visits with 1 visit in each trimester of pregnancy and 8 visits after delivery. Maternal data collection includes, socio-demographic and lifestyle factors, dietary intake, anthropometric measurements, physical activity, maternal psychological state, and blood samples for biochemical analysis. Post-partum, visits will take place when the child is 0.5, 4, 6, 9, 12, 18, and 24 months old, with data collection including infant anthropometric measurements, young child feeding practices, dietary intake, supplement use and the eating environment at home, as well as all maternal data collection described above, apart from blood samples. Additional data collection for the child includes developmental assessments taking place at three timepoints, 1) within 2 weeks of birth, 2) at 10-14 months and 3) at 22 - 26 months of age. Developmental assessments for the infant include vision, health, neurological examination, neurodevelopmental and sleep assessments.
Interventions
None listed
Sponsors
United Arab Emirates University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
16 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Emirati Nationality * Within first trimester of pregnancy (between 8 -12 weeks of gestation) * Singleton pregnancy * Absence of major illness preconception (Diabetes mellitus, hypertension, kidney disease, cancer, epilepsy, severe psychiatric illness, and other chronic diseases of infections such as autoimmune disorders, human immunodeficiency virus, and hepatitis).
Exclusion criteria
* Non-Emirati * Unconfirmed viable, intrauterine pregnancy at first obstetric ultrasound during first trimester * Twin or multiple gestation pregnancy and a history of multiple gestations * History of chronic illness (i.e., T2DM, hypertension, etc.) * Previously given birth to babies with malformation, intellectual disability, or inborn errors of metabolism. * Experience of a miscarriage before 28 weeks of gestation * On significant regular medications, including insulin, anti-hypertensive agents, psychotropic medications, anti-epileptic drugs, steroids, immune-suppressive agents, and chemotherapeutic agents.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maternal Dietary Intake | 1st Trimester One point during weeks 1 - 13 | 24 hour dietary recall |
| Maternal Weight | 1st Trimester - One point during weeks 1 - 13 | Measured in Kilograms |
| Maternal Blood Pressure | 1st Trimester - One point during weeks 1 - 13 | Measured sphygmomanometer, in millimetres of mercury. |
| Maternal Physical Activity | 2nd Trimester. One point during Weeks 14 - 26 | International Physical Activity Questionnaire |
| Child neurodevelopmental assessment | 24 months post-natal | INTERGROWTH-21st Neurodevelopment Assessment |
| Child anthropometric assessment (MUAC) | 0.5 months post-natal | Weight (kgs), length, head circumference, mid-upper arm circumference |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maternal zinc concentration | 1st Trimester - One point during weeks 1 - 13 | Serum zinc measured in micromole per litre |
| Maternal hemoglobin | 1st Trimester - One point during weeks 1 - 13 | Hemoglobin levels measured in grams per deciliter |
| Maternal lead concentration | 3rd Trimester One point during weeks 27 - 42 | Serum lead measured in micromole per litre |
| Maternal Ferritin | 1st Trimester - One point during weeks 1 - 13 | Serum ferritin measured in nanograms per milliliter |
| Maternal Folate | 1st Trimester - One point during weeks 1 - 13 | Serum folate measured in nanograms per milliliter |
| Maternal Vitamin D | 1st Trimester - One point during weeks 1 - 13 | Serum 25 hydroxyvitamin D measured in nanomole per liter |
| Maternal Vitamin A | 1st Trimester - One point during weeks 1 - 13 | Serum retinol measured in micrograms of retinol activity equivalent |
| Maternal Vitamin B12 | 1st Trimester - One point during weeks 1 - 13 | Serum B12 measured in picogram per millilitre |
Countries
United Arab Emirates
Outcome results
None listed