Burns Shock
Conditions
Keywords
burns; shock; recovery; human albumin; effect
Brief summary
To explore the effects and safety of human albumin in burn shock recovery, and then provide a theoretical basis for its rational use.
Detailed description
A retrospective case-control study was conducted. Patients who admitted to the burn ward and needed fluid resuscitation during the period of January 2011 to December 2018 in our unit were identified. Patients were divided into two groups according to the severity of burns, the patients with a 20%\<TBSA≤50% constituted the moderate and severe burn group, the patients with a TBSA\>50% constituted the severest burn group, and then the patients who used albumin for resuscitation constituted the albumin group, the patients who did not use albumin constituted the control group. The primary outcome was mortality, and the secondary outcomes included hospital stay, ventilator supporting, fluid use, and complications.
Interventions
DRUGAlbumin
At least one dose of human albumin was used for the patients during hospitalization in the burn ward consisted the albumin group. The patients who have no albumin use during their hospitalization in the burn ward consisted the control group.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 * TBSA≥ 20% （TBSA，the total burn area.） * Admitted to hospital within 24 hours after injury.
Exclusion criteria
* STB ≥ 33 μ mol/L * Cr ≥ 171 μ * Urine output l\< 500 ml / 24 h * Pregnant and lactating women * Severe combined injury * Glucocorticoids users * Immunosuppressants users * Patients survived less than 48 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the mortality of the patients | during the patients's hospitalization, an average of 1-2 month. | The mortality of the patients during their hospitalization. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the length of the patients's hospital stay | during the patients's hospitalization, an average of 1-2 month. | the Length of the patients's hospital stay,an average of 1-2 month. |
| the number of patients that using ventilators | during the patients's hospitalization, an average of 1-2 month. | the number of patients who using ventilators during their hospitalization |
| Volume of fluid used for resuscitationVolume of fluid used for resuscitation the volume of the patients's resuscitation fluid | during the patients's hospitalization, an average of 1-2 month. | the volume of the patients's resuscitation fluid using mL as the measurement |
| the number of complications that the patients occurred | during the patients's hospitalization, an average of 1-2 month. | the number of complications that the patients occurred during their hospitalization |
Outcome results
None listed